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Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Remarks:
According OECD 102 resp. EU A.1.
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 22 OCTOBER 2018 to 06 NOVEMBER 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
differential scanning calorimetry
Key result
Melting / freezing pt.:
> 179.6 °C
Decomposition:
no
Decomp. temp.:
> 188.76 °C
Sublimation:
no
Conclusions:
Therefore the melting point was determined as:
179.60 ± 0.12 °C (452.75 ± 0.12 K)
in a melting process from 167.92 °C to 188.76 °C (441.07 K to 461.91 K)

Description of key information

The determination of the melting point and boiling point of the test item 1-butyl-5-[(4-chlorophenyl)azo]-1,2-dihydro-6-hydroxy-4-methyl-2-oxonicotinonitrile should have been determined via DSC (differential scanning calorimetry).


As in the Pre-test for boiling point following Siwoloboff the test item showed signs of decomposition since 270 °C (indicated by colour change and physical state change) with vigorous reaction, after consulting with the sponsor only the determination of the melting point was performed using DSC.


The melting point was determined as:
179.60 ± 0.12 °C (452.75 ± 0.12 K) in a melting process from 167.92 °C to 188.76 °C (441.07 K to 461.91 K)


According to OECD 102 resp. EU A.1.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
179.6 °C

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