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EC number: 846-447-2
CAS number: 1219458-07-7
The oral acute toxicity of the test material was determined in an acute
oral toxicity test according to OECD 423 (MB Research 2017). The LD50
value was between >=300 mg/kg and <=2000 mg/kg bw.
The objective of the test was to determine the potential for oral
toxicity using the Acute Toxic Class Determination. This study was
designed to comply with the standards set forth in the current OECD
Guidelines for the Testing of Chemicals, Guideline 423. Guideline 423 is
referred to in OPPTS 870.1000 as an acceptable method to assess
lethality within a dose range.
Initially, three healthy female Sprague Dawley rats were dosed orally
with Benzylated Polyamine at 2000 mg/kg. Since the animals died, an
additional three healthy females were dosed at 300 mg/kg. There was one
death at this level, so an additional three males were dosed as a
confirmatory group at 300 mg/kg. The rats were observed at 15 minutes,
1, 2 and 4 hours postdose and once daily for 14 days for toxicity and
pharmacological effects, and twice daily for mortality. Body weights
were recorded immediately pretest, weekly, at death and at termination
in the survivors. All animals were examined for gross pathology. The
test article was assigned to a toxic category based on the mortality
The oral LD50 of the test material is greater than 300 mg/kg but less
than 2000 mg/kg of body weight in rats and is therefore considered to be
in GHS Category 4
according to CLP regulation 1272/2008.
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