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EC number: 846-447-2 | CAS number: 1219458-07-7
The oral acute toxicity of the test material was determined in an acute oral toxicity test according to OECD 423 (MB Research 2017). The LD50 value was between >=300 mg/kg and <=2000 mg/kg bw.
The objective of the test was to determine the potential for oral toxicity using the Acute Toxic Class Determination. This study was designed to comply with the standards set forth in the current OECD Guidelines for the Testing of Chemicals, Guideline 423. Guideline 423 is referred to in OPPTS 870.1000 as an acceptable method to assess lethality within a dose range.
Initially, three healthy female Sprague Dawley rats were dosed orally with Benzylated Polyamine at 2000 mg/kg. Since the animals died, an additional three healthy females were dosed at 300 mg/kg. There was one death at this level, so an additional three males were dosed as a confirmatory group at 300 mg/kg. The rats were observed at 15 minutes, 1, 2 and 4 hours postdose and once daily for 14 days for toxicity and pharmacological effects, and twice daily for mortality. Body weights were recorded immediately pretest, weekly, at death and at termination in the survivors. All animals were examined for gross pathology. The test article was assigned to a toxic category based on the mortality response noted.
The oral LD50 of the test material is greater than 300 mg/kg but less than 2000 mg/kg of body weight in rats and is therefore considered to be in GHS Category 4
according to CLP regulation 1272/2008.
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