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EC number: 202-384-7 | CAS number: 95-02-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 April 2010 - 15 November 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
Test material
- Reference substance name:
- 4-amino-2-methylpyrimidine-5-methylamine
- EC Number:
- 202-384-7
- EC Name:
- 4-amino-2-methylpyrimidine-5-methylamine
- Cas Number:
- 95-02-3
- Molecular formula:
- C6H10N4
- IUPAC Name:
- 5-(aminomethyl)-2-methylpyrimidin-4-amine
- Details on test material:
- - Name of test material (as cited in study report):grewe-diamin
- Physical state: solid
Constituent 1
Results and discussion
Water solubilityopen allclose all
- Water solubility:
- 392.4 g/L
- Temp.:
- 10 °C
- pH:
- 11.3 - 11.4
- Remarks on result:
- other: standard deviation: 11.3, replicates of three days
- Water solubility:
- 427.3 g/L
- Temp.:
- 20 °C
- pH:
- 11.3 - 11.4
- Remarks on result:
- other: standard deviation: 15.8, replicates of three days
- Details on results:
- The temperature of the water bath was 10.0 °C respectively 20.0 °C.
The pH of the solutions were 11.3 to 11.4 at 10 °C and 20 °C.
The difference between the concentrations of the test substance of day 1 to 3 at 10 °C
and 20 °C was <15 % and the concentrations of the test substance showed no relevant tendency. Therefore the mean of day 1 - 3 was taken as the
solubility of the test substance at both temperatures, according to the guidelines.
The water solubility of "Grewe-diamin" was determined to:
Mean: 392.4 g/L, standard deviation: 11.3, replicates of three days, temperature 10.0 °C.
Mean: 427.3 g/L, standard deviation: 15.8, replicates of three days, temperature 20.0 °C.
As the temperature coefficient of the solubility of the test substance was <3 % (i.e. 0.9 %) per °C, the solubility was not determined at three
temperatures, in agreement with the guideline.
Any other information on results incl. tables
Table1: Water Solubility at 10 °C
Mass concentration of"Grewe-diamin"determined at different times of stirring, two solutions were used.
nominal temperature |
equilibration time |
pH of the solutions |
concentration (mg/L) |
deviation from the maximum concentration |
|||
1st |
2nd |
1st |
2nd |
mean |
|||
10 °C |
1 day |
11.3 |
11.4 |
399650 |
411409 |
405529 |
0.0 |
2 days |
11.3 |
11.4 |
386750 |
384561 |
385655 |
-4.9 |
|
3 days |
11.3 |
11.3 |
385852 |
386355 |
386104 |
-4.8 |
|
|
|
|
mean (day 1-3) |
392429 |
|
||
|
|
|
SD |
11347 |
|
Table2: Water Solubility at 20 °C
Mass concentration of"Grewe-diamin"determined at different times of stirring, two solutions were used.
nominal temperature |
equilibration time |
pH of the solutions |
concentration (mg/L) |
deviation from the maximum concentration |
|||
1st |
2nd |
1st |
2nd |
mean |
|||
20 °C |
1 day |
11.3 |
11.4 |
406682 |
413083 |
409882 |
-7.0 |
2 days |
11.3 |
11.3 |
442557 |
438762 |
440660 |
0.0 |
|
3 days |
11.4 |
11.3 |
431982 |
430437 |
431210 |
-2.1 |
|
|
|
|
mean (day 1-3) |
427251 |
|
||
|
|
|
SD |
15765 |
|
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of "Grewe-diamin" was determined to:
Mean: 392.4 g/L, standard deviation: 11.3, replicates of three days, temperature 10.0 °C.
Mean: 427.3 g/L, standard deviation: 15.8, replicates of three days, temperature 20.0 °C.
As the temperature coefficient of the solubility of the test substance was <3 % (i.e. 1.8 %) per °C, the solubility was not determined at three
temperatures, in agreement with the guideline. - Executive summary:
The flask method was used.
The temperature of the water bath was 10.0 °C respectively 20.0 °C.
The pH of the solutions were 11.3 to 11.4 at 10 °C and 20 °C.
The difference between the concentrations of the test substance of day 1 to 3 at 10 °C
and 20 °C was <15 % and the concentrations of the test substance showed no relevant tendency. Therefore the mean of day 1 - 3 was taken as the solubility of the test substance at both temperatures, according to the guidelines.The water solubility of"Grewe-diamin"was determined to:
Mean: 392.4 g/L, standard deviation: 11.3, replicates of three days, temperature 10.0 °C.
Mean: 427.3 g/L, standard deviation: 15.8, replicates of three days, temperature 20.0 °C.As the temperature coefficient of the solubility of the test substance was <3 % (i.e. 0.9 %) per °C, the solubility was not determined at three temperatures, in agreement with the guideline.
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