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Diss Factsheets

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
29 April 2010 - 15 November 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
GLP compliance:
yes
Type of method:
capillary method

Test material

Constituent 1
Chemical structure
Reference substance name:
4-amino-2-methylpyrimidine-5-methylamine
EC Number:
202-384-7
EC Name:
4-amino-2-methylpyrimidine-5-methylamine
Cas Number:
95-02-3
Molecular formula:
C6H10N4
IUPAC Name:
5-(aminomethyl)-2-methylpyrimidin-4-amine
Details on test material:
- Name of test material (as cited in study report): grewe-diamin
- Physical state: solid

Results and discussion

Melting / freezing point
Melting / freezing pt.:
> 120 - < 129 °C
Atm. press.:
1 atm
Decomposition:
no
Sublimation:
no

Applicant's summary and conclusion

Conclusions:
"Grewe-diamin" melted between 120 °C and 129 °C.
The difference between the temperature at the beginning and at the final stage of melting is not within the limits of the accuracy of the method
(+-0.5 °C) and therefore no melting point but a melting range was stated. The test substance melted in the range of 120 to 129 °C.


Executive summary:

The determination of the melting temperature of the test substance was performed by the capillary method with hot block heating.

"Grewe-diamin" melted between 120 °C and 129 °C. The difference between the temperature at the beginning and at the final stage of melting is not within the limits of the accuracy of the method (+-0.5 °C) and therefore no melting point but a melting range was stated. The test substance melted in the range of 120 to 129 °C.