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EC number: 700-261-7
CAS number: 4427-96-7
Kinetics (metabolism, distribution and excretion) are considered to be similar for oral and inhalation intake.
Starting point: NOAEL of 30 mg/kg bw/day in the repeated oral study in rats.Conversion of an oral NOAEL into a corrected NOAEC:For workers (8h exposure/day), the corrected inhalatory NOAEC = oral NOAEL * 1/sRVrat * ABSoralrat/ABSinhal-human * sRVhuman/wRV= 30 * 1/0.38 m3/kg/8h * 1 * 6.7 m3 (8h)/10 m3(8h)= 30 /0.38 * 1* (6.7/10) = 53 mg/m3
assume 100% dermal absorption
Kinetics (metabolism, distribution and excretion) are considered to be similar for oral and inhalation intake.For the general population (24h exposure/day), the corrected inhalatory NOAEC = oral NOAEC * 1/sRVrat * ABSoral-rat /ABSinhal-human= 30 * 1/1.15 m3/kg * ABSoral-rat /ABSinhal-human= 30 * 1/1.15 m3/kg * 1 = 26 mg/m3
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