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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and acceptable for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EPA OPP 81-5 (Acute Dermal Irritation)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Divanadyl pyrophosphate
EC Number:
407-130-0
EC Name:
Divanadyl pyrophosphate
Cas Number:
65232-89-5
Molecular formula:
(VO)2P2O7
IUPAC Name:
Divanadyl pyrophosphate
Details on test material:
- Name of test material (as cited in study report): E-326 Catalyst
- Physical state: greyish-green powder
- Analytical purity: 100%
- Lot/batch No.: 3883559 A
- Storage condition of test material: room temperature

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Hazleton Research Animals Inc., Denver, Pennsylvania.
- Age at study initiation: young adults (at least 8 weeks old)
- Weight at study initiation: no data
- Housing: individually
- Diet: Lab Rabbit Chow HF (Purina #5326), 125 g/day while on test.
- Water: tap water, ad libitum.
- Acclimation period: 55 days.

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16 - 21 °C
- Humidity (%): 30 - 70 %
- Photoperiod (hrs dark / hrs light): 12 h / 12 h

Test system

Type of coverage:
semiocclusive
Preparation of test site:
other: closely clipped
Vehicle:
physiological saline
Controls:
other: untreated skin of the same animals served as control
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 grams per site; two intact sites per animal
- % coverage: at least 10 % of the body area

VEHICLE
- Amount(s) applied (volume or weight with unit): 0.25 ml
Duration of treatment / exposure:
4 h
Observation period:
3 days
Number of animals:
6 (2 males, 4 females).
Details on study design:
TEST SITE
- Type of wrap if used: gauze and porous tape

REMOVAL OF TEST SUBSTANCE
- Washing (if done): excess test material was removed using dry gauze.
- Time after start of exposure: 4 h

SCORING SYSTEM: draize score

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24 h - 48 - 72 h
Score:
0.1
Max. score:
4
Reversibility:
fully reversible within: 72 h
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24 h - 48 h - 72 h
Score:
0
Max. score:
4
Reversibility:
other: no effects

Any other information on results incl. tables

Erythema findings: right front/left front:

 Time  animal 1  animal 2  animal 3  animal 4  animal 5 animal 6
 0,5 h  1/0 0/1   0/0  0/1  0/0  0/0
 24 h  0/1  0/0  0/0  0/1  0/0  0/0
 48 h  1/1  0/0  0/0  0/1  0/0  0/0
 72 h  0/0  0/0  0/0  0/0  0/0  0/0

Edema findings: right front/left front:

 Time  animal 1  animal 2  animal 3  animal 4  animal 5 animal 6
 0,5 h  0/0   0/0  0/0    0/0   0/0   0/0
 24 h   0/0   0/0   0/0   0/0   0/0  0/0
 48 h   0/0   0/0   0/0   0/0  0/0   0/0
 72 h   0/0   0/0   0/0  0/0   0/0   0/0

Applicant's summary and conclusion