Registration Dossier
Registration Dossier
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EC number: 618-920-1 | CAS number: 93280-40-1
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The lowest chronic NOEC, 560 µg V/L, was observed in a 14-week chronic study on the effect of NaVO3 on ephippia production by Daphnia magna (Van Der Hoeven, 1990; Klimisch 2).
Corrected for the molecular weight of vanadylhydrogenphosphate-hemihydrate (CAS no. 93280-40-1): 14-week NOEC = 1905 µg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 1 905 µg/L
Additional information
Data on the long-term toxicity of vanadylhydrogenphosphate-hemihydrate (CAS no. 93280-40-1) to aquatic invertebrates are not available; therefore, a read-across approach to structurally similar pentavalent vanadium substances was performed.
A study on the population dynamics by Van der Hoeven (1990) was selected as key study. The number and size of Daphnia magna as well as the production of ephippia were observed over a period of 14 weeks. The test system was running under flow-through conditions (test solution including algae and yeast as nutrition for the test animals). The test was performed in duplicate with 10 animals in total at test start. The photoperiod was 14 h light / 10 h dark. The test concentrations were not analytically verified. Population peaks were observed in the controls and the test solutions. Low concentrations of sodium metavanadate (CAS 13718-26-8) rendered population peaks less regular. Sodium metavanadate promoted the formation of ephippia (NOEC = 560 µg/L V). The supporting study was a reproduction study with Daphnia magna according to 84/449/EEC which is similar to the current OECD 211 guideline (Beusen & Neven, 1987). The test substance was also sodium metavanadate (CAS 13718-26-8).The test concentrations were analytically verified. The measured concentrations were within 10% of nominal concentrations. The test was performed under semi-static conditions. The 23-d MATC (= maximum acceptable toxicant concentration) was 1900 µg/L V (nominal), which was converted to a NOEC of 1344 µg/L V (NOEC = MATC/sqrt(2)).
A further long-term toxicity study with divanadium pentaoxide (CAS 1314-62-1; Kimball, 1978) as test substance was disregarded as there was evidence in the raw data that the general health condition of all test species (incl. control organism) was decreasing with time (lower survival, reproduction).
For the assessment of the toxicity of vanadylhydrogenphosphate-hemihydrate (CAS no. 93280-40-1), the effect value based on the vanadium concentration must be corrected for the molecular weight of vanadylhydrogenphosphate-hemihydrate (29.4% V). The corrected 14 -wk NOEC is 1905 µg/L (= 560 µg V/L).
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