Registration Dossier
Registration Dossier
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EC number: 608-174-5 | CAS number: 28183-82-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Review
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Because the substance is in part polymer, assessment of toxicity has been carried out through consideration of the constituents and fragements found during MS analysis. This was considered to be a viable alternative to animal testing.
New animal studies cannot be justified on a class of high molecular weight amines where the low molecular weight fragments and reaction products are of low toxicity.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Review of information from different sources
- GLP compliance:
- not specified
- Remarks:
- Some sources of information may have been GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-Propenenitrile, polymer with 1,2-ethanediamine
- EC Number:
- 608-174-5
- Cas Number:
- 28183-82-6
- IUPAC Name:
- 2-Propenenitrile, polymer with 1,2-ethanediamine
- Test material form:
- liquid: viscous
- Details on test material:
- Named in some reports as 2-propenenitrile, polymer with 1,2-ethanediamine
Dried material, described as viscous liquid, is used for some tests.
Constituent 1
- Specific details on test material used for the study:
- Review based on consistuents and fragments identified in Section 1.2 of the dossier
Test animals
- Species:
- rat
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- In view of potential corrosivity, vehicles were important in some cases to avoid local irritation masking systemic effects
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None reported
- Clinical signs:
- other: Other than local irritation, not reported
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Except where the low moleuclar weight amines were severely irritant, there was no effect on toxiciy.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
