Registration Dossier
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EC number: 608-174-5 | CAS number: 28183-82-6
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Ready biodegradfation extended to 60 day period - performed 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Guideline study, but extended to assess potential for inherent biodegradation.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 A (Ready Biodegradability: DOC Die Away Test)
- Version / remarks:
- Extended to 60 days
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Batch BP16120710, supplied as 50% in water.
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- Non-adapted from municiple treatment works
- Duration of test (contact time):
- 60 d
- Initial conc.:
- ca. 2 mg/L
- Based on:
- act. ingr.
- Parameter followed for biodegradation estimation:
- DOC removal
- Reference substance:
- acetic acid, sodium salt
- Parameter:
- % degradation (DOC removal)
- Value:
- ca. 3
- Sampling time:
- 13 d
- Parameter:
- % degradation (DOC removal)
- Value:
- ca. 6
- Sampling time:
- 20 d
- Parameter:
- % degradation (DOC removal)
- Value:
- ca. 18
- Sampling time:
- 28 d
- Parameter:
- % degradation (DOC removal)
- Value:
- ca. 22
- Sampling time:
- 60 d
- Details on results:
- Significant lag period with little biodegradation.
Slow rate of biodegradation over 60 days, but likely ultimately biodegradable. - Validity criteria fulfilled:
- yes
- Interpretation of results:
- inherently biodegradable, not fulfilling specific criteria
- Conclusions:
- Significant lag period with little biodegradation; this was anticipated from modelling and the 60 day study was planned with this in mind.
However, total biodegradation was expected to be significantly higher from modelling.
Reference
Description of key information
Significant lag period with little biodegradation; this was anticipated from modelling and the 60 day study was planned with this in mind.
However, total biodegradation was expected to be significantly higher from modelling.
The results for the seawater study showed initial biodegradation that slowed by Day 20 with no further biodegradation.
Seawater studies without added innoculum are hard to pass and it is predicted that higher levels of biodegradation woudl be seen using sewage innoculum in a freshwater study.
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable, not fulfilling specific criteria
Additional information
[Type of water: marine water]
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