Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Justification for type of information:
The precise temperature was not recorded (methods followed are at 'ambient' temperature)
The pH was not reported (performed at 'natural' pH, ca pH 10)
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
Not specifed if material was 'water-free' (dried) material, but the presence of water would not make a difference with this method.
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
< 0
Temp.:
20 °C
pH:
ca. 10
Remarks on result:
other: Precise figure not possible to determine
Details on results:
The test material eluted close to the solvent front and appeared not to be retained in the column, suggesting a Log Kow < 0
Only a single peak was observed using Refractive Index detector and Diode Array Detector.
The precise temperature was not recorded (methods followed are at 'ambient' temperature)
The pH was not adjusted.
Conclusions:
The very high water solubility would suggest that the partition coefficient is unlikely to be > 1 and despite some methodological deficiencies, the result is conclusive.
Only a single HPLC peak was reported, but in view of the type of column and mobile phase, the different speicies of the UVCB would not appear separate under the conditions of the test; this does however demonstrate that there are no minor components with a significant partition coefficient.

Description of key information

Key value for chemical safety assessment

Log Kow (Log Pow):
0
at the temperature of:
20 °C

Additional information

The very high water solubility would suggest that the partition coefficient is unlikely to be > 1 and despite some methodological deficiencies, the result is conclusive.

Only a single HPLC peak was reported, but in view of the type of column and mobile phase, the different species of the UVCB would not appear separate under the conditions of the test; this does however demonstrate that there are no minor components with a significant partition coefficient.