Registration Dossier
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EC number: 701-173-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
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- Auto flammability
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- Oxidising properties
- Oxidation reduction potential
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- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
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- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to aquatic plants other than algae
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic plants other than algae
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Very complete and well documented study that gives proper information on the potential consequences of an accidental spill in standing waters.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Mecocosm study.
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Concentration in water lower or close to detection limit level (~0.005 mg/l) throughout the study period. Approximately 100% of the substance was found in the sediment as hardened material at the end of the study period.
- Details on test solutions:
- Substance added directly onto the bottom of the ponds with a hose.
- Test organisms (species):
- other: other aquatic plant: macrophytes
- Details on test organisms:
- macrophytes (Potamogeton crispus and Zannichellia palustris).
- Test type:
- other: mecocosm
- Water media type:
- freshwater
- Total exposure duration:
- 112 d
- Post exposure observation period:
- Test parameter: fluctuations of biomass.
- Hardness:
- Measurements were taken at approximately every 2 weeks.
Overall the control pond had a hardness of about 4°dH (corresponding to about 40mg CaO/l) and remained fairly steady throughout the study period. Following production of carbon dioxide from applied PMDI, results from the treated ponds showed a dose related increase of hardness. Values as high as approximately 10°dH were obtained at the end of the study period for the high dose pond. - Test temperature:
- During the first days after application, temperature was measured two to three times a day and thereafter several times a week. The temperature fluctuated between 18 and 23°C. In general there were no differences between the three ponds during the entire study period.
- pH:
- During the first days after application, pH was measured two to three times a day and thereafter several times a week. The pH of the control pond typically ranged, on average, from approximately pH8 to pH9. The pH of the high dosed pond rapidly declined following application and overall the pH of this pond was approximately 2.0 units lower on average than in the control pond. The pH of the low dosed pond was slightly lower than in the control pond for the whole study.
- Dissolved oxygen:
- During the first days after application, dissolved oxygen was measured two to three times a day and thereafter several times a week. Dissolved oxygen varied between 9 and 22mg/l, values indicating high productivity of the phytoplankton and macrophytes which result in concentrations well above the oxygen saturation at these temperatures. Up to approximately 25 days the oxygen concentrations in all three test ponds corresponded very well. Thereafter oxygen concentrations in the treated ponds were higher than those in the control pond.
- Nominal and measured concentrations:
- 1000 and 10000 mg/l
- Details on test conditions:
- Three 4.5 m3 ponds filled with groundwater and added natural lake sediment (15 cm); the systems were left outdoors for six months. Links between ponds were then closed; fish were added to ponds (in cages) and substance added to two ponds at two different concentrations (1000 and 10 000 mg/l), the last one being the control.
- Reference substance (positive control):
- not specified
- Duration:
- 112 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Remarks on result:
- other: Biomass was significantly higher in the presence of MDI (42% higher in the high-dosed pond and 14 % in the low -dosed pond) due to increased CO2 in the water.
- Conclusions:
- MDI applied polymerized and formed a stable layer on the sediment surface of the ponds. At the end of the study, approximately 100% of the substance was found in the sediment as hardened material.
Reference
Although macrophyte abundance was severely affected in the treated ponds because of physical obstruction, their biomass was significantly higher in the presence of MDI (42% higher in the high-dosed pond and 14 % in the low -dosed pond) due to increased CO2 in the water.
Description of key information
Not required by REACH annexes. However, a mesocosm study (Heimbach, 1993) with PMDI exists in which the toxicity towards macrophytes
(Potamogeton crispus and Zannichellia palustris) was assessed. No toxicity was observed at a loading of 1000 and 10,000 mg/L.
Key value for chemical safety assessment
Additional information
The test substance is covered by the category approach of methylenediphenyl diisocyanates (MDI). Hence, data of the category substances can be used to cover this endpoint. The read-across category justification document is attached in IUCLID section 13. It is important to note that the MDI category approach for read-across of environmental and human hazards between the MDI substances belonging to the MDI category is work in progress under REACH. Therefore the read-across document should be considered a draft.
In a mesocosm study, a pond was exposed to a loading of 1000 and 10,000 mg/L of PMDI during 112 days. Three 4.5 m3 ponds were filled with groundwater and added natural lake sediment (15 cm). The systems were left outdoors for six months. Links between ponds were then closed; fish were added to ponds (in cages) and substance added to two ponds at two different loadings (1000 and 10,000 mg/L). The third pond was the control. The substance was added directly onto the bottom of the ponds with a hose. The toxicity effects were assessed to two macrophytes, Potamogeton crispus and Zannichellia palustris. No effects were seen at both loadings. The MDI applied polymerized and formed a stable layer on the sediment surface of the ponds. At the end of the study, approximately 100% of the substance was found in the sediment as hardened material.
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