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EC number: 701-173-1 | CAS number: -
Observation Period (Day)
All animals appeared normal prior to dosing AN = Appears normal
The purpose of this study was to assess the toxicity of the test article following a single oral dose to the rat. The results of the study are believed to be of value in predicting the likely toxicity in man by the oral route.
Initially, one female Sprague Dawley rat was dosed at 175 mg/kg. No mortality was observed at 175 mg/kg and dosing continued in another female at 550 mg/kg. Dosing continued in an additional female at 2000 mg/kg as per protocol guidelines and then in one female at 5000 mg/kg. Based on these results two additional females were dosed at 5000 mg/kg. A total of 6 females were dosed. Mortality checks were made once daily. Clinical observations were recorded prior to dosing, as well at 30 minutes, 4 hours post-dose, and daily thereafter through Day 15. Body weights were recorded on the day of dosing (Day 1), and on Days 8 and 15. All rats were euthanized by CO2asphyxiation and necropsied on Day 15. For doses of 175, 550, 2000 or 5000 mg/kg, no mortality was observed. All animals appeared normal throughout the study at 175, 550, 2000 and 5000 mg/kg. No biologically significant effect was seen on body weights on Days 8 and 15. Terminal necropsy revealed no visible lesions in any of the animals at 175, 550, 2000 and 5000 mg/kg.
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