Registration Dossier
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EC number: 701-173-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
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- Additional physico-chemical information
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- Endpoint summary
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- Environmental data
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Sediment toxicity
- Terrestrial toxicity
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- Toxicological Summary
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- Acute Toxicity
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Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented report but with some deviations from standard method and no analytical monitoring reported.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Vehicle:
- no
- Details on test solutions:
- Test substance added to test vessels and dispersed by slight stirring with a glass rod.
- Test organisms (species):
- activated sludge
- Details on inoculum:
- Strain/source: activated sludge from laboratory plant
Breeding method: bacteria fed with synthetic sewage consisting of peptone meat extract urea and some inorganic salts as in guideline.
Control: yes. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Post exposure observation period:
- Test parameter: inhibition of respiration.
- Nominal and measured concentrations:
- 1, 10 and 100 mg/l.
- Details on test conditions:
- no details provided.
- Reference substance (positive control):
- yes
- Remarks:
- 3.5-dichlorophenol
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Details on results:
- Exposed: 0% inhibition of respiration with any of the tested concentrations. (respiration rate 0.5 mg/l min).
Control: respiration rate: 0.5 mg/l min - Results with reference substance (positive control):
- Respiration rate with 1 mg/l: 0.4 mg/l min
respiration rate with 100 mg/l: 0 mg/l min
Reference
Description of key information
Based on the respiration rate using activated sludge, the 3h-EC50 for the test substance was found to be >100 mg/L (Caspers et al, 1986), following an OECD 209 Activated Sludge, Respiration Inhibition Test.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 100 mg/L
Additional information
The test substance is covered by the category approach of methylenediphenyl diisocyanates (MDI). Hence, data of the category substances can be used to cover this endpoint. The read-across category justification document is attached in IUCLID section 13. It is important to note that the MDI category approach for read-across of environmental and human hazards between the MDI substances belonging to the MDI category is work in progress under REACH. Therefore the read-across document should be considered a draft.
An OECD 209 Activated Sludge, Respiration Inhibition Test is available for PMDI. Based on the respiration rate using activated sludge, the 3h-EC50 was found to be >100 mg/L, which was the highest concentration tested (Caspers et al, 1986). This value may be used for the derivation of a PNECstp.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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