Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 252-044-7 | CAS number: 34455-00-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Remarks:
- No deviations occurred that impacted the integrity of the study.
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- 1,1,2,2,3,3,4,4,4-nonafluoro-N,N-bis(2-hydroxyethyl)butane-1-sulphonamide
- EC Number:
- 252-044-7
- EC Name:
- 1,1,2,2,3,3,4,4,4-nonafluoro-N,N-bis(2-hydroxyethyl)butane-1-sulphonamide
- Cas Number:
- 34455-00-0
- Molecular formula:
- C8H10F9NO4S
- IUPAC Name:
- 1,1,2,2,3,3,4,4,4-nonafluoro-N,N-bis(2-hydroxyethyl)butane-1-sulfonamide
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 3M Company, Lot 38015
- Expiration date of the lot/batch: April 20, 2018
- Purity test date: April 20, 2017
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: reported as "Room temperature and humidity"
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: The test article was individually weighed and moistened with distilled water to form a paste consistency.
FORM AS APPLIED IN THE TEST: Moistened with water to form a paste.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, Stone RIdge, NY
- Females (if applicable) nulliparous and non-pregnant: Yes
- Age at study initiation: 8 weeks
- Weight at study initiation: Male range: 263-282 g, Female range: 208-229 g
- Fasting period before study: None
- Housing: Individually in suspended wire-bottom cages.
- Diet (e.g. ad libitum): PMI Rat Chow (Diet No. 5012) ad libitum
- Water (e.g. ad libitum): Tap water ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data in final report but it did not deviate from the guideline-specified temperature range.
- Humidity (%): No data in final report but it did not deviate from the guideline-specified humidity range.
- Air changes (per hr): No data in final report but it did not deviate from the guideline-specified air change range.
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 25 May, 2017 To: 15 June, 2017
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: The test article was moistened with distilled water to create a paste.
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Dorsal
- % coverage: 10% of body surface
- Type of wrap if used: Porous dressing and porous non-irritating tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Distilled water
- Time after start of exposure: 24 hours.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/kg body weight
- For solids, paste formed: yes - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations for mortality, toxicity and clinical signs were recorded at one and four hours postdosing and once daily thereafter for 14 days. Body weights were recorded pre-test, weekly and at termination.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Immediately following unwrapping, erythema was absent to very slight and edema was absent. By Day 14, erythema edema were absent.
- Mortality:
- No mortality occurred during the study period.
- Clinical signs:
- other: Chromorhinorrhea and wetness of the anogenital area were observed.
- Gross pathology:
- No abnormalities were observed upon necrospy.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the results of the study, the dermal LD50 of the test article is greater than 2,000 mg/kg body weight.
- Executive summary:
The dermal lethality potential of the test article was evaluated in male and female Sprague Dawley rats. The study was performed in compliance with OECD GLP regulations. The test was performed according to OECD 402. Rats (5 males and 5 females) received a 24-hour dermal exposure of 2000 mg/kg. The test article was moistened with distilled water on porous gauze and applied to the dorsal region (clipped, 10% body surface) of each rat. The exposure site was wrapped with porous dressing and porous non-irritating tape (semi-occlusive). After 24 hours the gauze was removed and any remaining test article was removed by washing with distilled water. All rats survived the study. Clinical observations included chromorhinorrhea and wetness of the anogenital area. Immediately following unwrapping, erythema was absent to very slight and edema was absent. By Day 14, erythema and edema were absent. Based on the results of the study, the rat dermal LD50 of the test article is greater than 2,000 mg/kg body weight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
This website uses cookies to ensure you get the best experience on our websites.