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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1992
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
INITIAL SUBMISSION: ACUTE ORAL AND DERMAL TOXICITY OF M-PHENOXYPHENOL IN RATS, MICE, AND GUINEA PIGS WITH COVER LETTER DATED 090892
Author:
U.S. Environmental Protection Agency
Year:
1992
Bibliographic source:
EPA-OTS0570999

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Intraperintoneally route
No other data specified
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
No specified

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Details on exposure:
No specified
Doses:
200 - 3 200 mg/kg
No. of animals per sex per dose:
Total : 10 rats
Control animals:
no
Details on study design:
No specified
Statistics:
No specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 200 - < 400 mg/kg bw
Based on:
test mat.
Mortality:
Time of deah : 0.5 hours - 6 days
Clinical signs:
Moderate to very weak, severe ataxia, prostration, vasodilatation, tremor, jerking, temporary hind quarter paralysis.
Body weight:
Yes
Gross pathology:
No specified
Other findings:
No specified

Applicant's summary and conclusion

Conclusions:
The approximative LD50 for rat, intraperintoneally, is 200 - 400 mg/kgbw.
Executive summary:

The approximative LD50 for rat, intraperintoneally, is 200 - 400 mg/kgbw.