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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1992
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
INITIAL SUBMISSION: ACUTE ORAL AND DERMAL TOXICITY OF M-PHENOXYPHENOL IN RATS, MICE, AND GUINEA PIGS WITH COVER LETTER DATED 090892
Author:
U.S. Environmental Protection Agency
Year:
1992
Bibliographic source:
EPA-OTS0570999

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Version / remarks:
No detailed data but U.S EPA validation.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Specific details on test material used for the study:
Not specified

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
Not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
Not specified
Doses:
Dose range : 200- 3200 mg/kgbw
No. of animals per sex per dose:
Total : 10 rats
Control animals:
no
Details on study design:
Not specified
Statistics:
Not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 1 600 mg/kg bw
Based on:
test mat.
Mortality:
Time of Death : 1 day
Clinical signs:
Moderate to quite weak, rough coat, tremors, sides caved in, prostration, excess salivation.
All rats had slight vasodilatation and temporary paralysis of hind quarters
Body weight:
Yes
Gross pathology:
Not specified
Other findings:
Not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The approximative LD50 (rat) for 3-PhenxyPhenol, per oral, is 1 600 mg/kgbw.
Executive summary:

The approximative LD50 (rat) for 3-PhenxyPhenol, per oral, is 1 600 mg/kgbw.