Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003-2004
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004
Report Date:
2004

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test organisms

Test organisms (species):
Daphnia magna

Test conditions

Hardness:
2.5 mg CaCO3/L

Results and discussion

Effect concentrationsopen allclose all
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Duration:
48 h
Dose descriptor:
EC100
Effect conc.:
> 100 mg/L

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
In the control and at the test item concentration of 100 mg/L, no immobilized test organisms
were observed during the test period of 48 hours.
Executive summary:

The acute toxicity of the test item ucb 22060 to Daphn~a magna was determined in a 48-hour static test according to the EU Commission Directive 92/69/EEC, Part C.2 (1992), and the OECD Guideline for Testing of Chemicals, No. 202, Part I (1984). A limit test was performed in accordance with the EU Commission Directive 92/69/EEC to demonstrate that the test item has no toxic effect on the test organisms up to and including a nominal concentration of 100 mg/L. Thus, the only concentration tested was nominal 100 mg/L and a control. The test item concentration in the samples from the start and the end of the test was 94 and 102 % of the nominal value, respectively. Under the conditions of the test, the test item ucb 22060 was stable during the test period of 48 hours. Therefore, all reported results are related to the nominal concentration of the test item. In the control and at the test item concentration of 100 mg/L, no immobilized test organisms were observed during the test period of 48 hours. The 48-hour NOEC (highest concentration tested without toxic effects after the exposure period of 48 hours) and the 48-hour ECO of ucb 22060 to Daphnia magna were determined to be at least 100 mg/L. These values might even be higher but concentrations above 100 mg/L were not tested, according to the EU Commission Directive. The 48-hour EC50 and the 48-hour ECI 00 were clearly higher than 100 mg/L. These values could not be quantified due to the absence of toxicity of ucb 22060 at the test concentration of 100 mg/L.