Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003-2004
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004
Report Date:
2004

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test solutions

Details on test solutions:
Identity and concentration of auxiliary solvent for dispersal: None.

Test organisms

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)

Study design

Test type:
semi-static

Test conditions

Hardness:
250 mg CaCO3/L

Results and discussion

Effect concentrationsopen allclose all
Duration:
24 h
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Basis for effect:
mortality
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Basis for effect:
mortality
Duration:
72 h
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Basis for effect:
mortality
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Basis for effect:
mortality
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
> 100 mg/L
Basis for effect:
mortality
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
100 mg/L
Details on results:
%Concentration loss over test: 0 ...

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
In the control and at the test concentration of 100 mg/L no mortality
abnormalities were determined during the test period of 96 hours.
Executive summary:

The acute toxicity of the test item ucb 22060 to zebra fish (Brachydanio rerio) was determined in a 96-hour static test according to the EU Commission Directive 92/69/EEC, Part C.1 (1992), and the OECD Guideline for Testing of Chemicals No. 203, (1992). A limit test was performed in accordance with the guidelines to demonstrate that the test item has no toxic effect on the test organisms at the nominal concentration of 100 mg/L. Thus the only concentration tested was nominal 100 mg/L and a control. In the control and at the test concentration of 100 mg/L no mortality abnormalities were determined during the test period of 96 hours. Therefore, the 96-hour NOEC (highest concentration tested without toxic exposure period of 96 hours), and the 96-hour LCO of ucb 22060 to or other visible effects after the zebra fish were determined to be at least 100 mg/L. The NOEC and the LCO might even be higher than this concentration, but concentrations in excess of 100 mg/L have not been tested, according to the guidelines. The 96-hour LOEC (lowest concentration with toxic effects), the 96-hour LC50 and the 96-hour LCI 00 were clearly higher than 100 mg/L. These values could not be quantified due to the absence of toxicity of ucb 22060 at the tested concentration.