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EC number: 446-640-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- -0.7
- Temp.:
- 20 °C
- pH:
- ca. 4.89
Applicant's summary and conclusion
- Conclusions:
- During the preliminary test, the log Pow of ucb 22060 was estimated to be -1.3. Therefore
the flask shaking method was chosen to conduct the main test.
During the main study, three tests were carried out, each in duplicate, with volume ratios of
both solvents of 1:1, 2:1 and 1:2. After equilibration the concentration of the test item was
determined in every phase by HPLC. The results of the individual measurements are
summarised in Table 3. The tabulated values represent rounded results, which were obtained
by calculation using the exact raw data. The log Pow was calculated for each of the six
vessels and was found to be in the range of -0.65 to – 0.67.
In order to check the anal~tcal work, the mass balance for each vessel was calculated, too,
and the recovery of the test item was found to be in the range of 97 YO to 99 Yo. Details are
given in Table 4. The tabulated results represent rounded-off values obtained by calculations
based on the exact raw data.
A typical chromatogram of a standard solution is given in Figure 3. A typical chromatogram of
an aqueous sample solution is given in Figure 4. A typical chromatogram of a sample
solution in n-octanol is given in Figure 5. The calibration data for test item-standards are
given in Table 5. The r’ fit was 0.9999 (optimum 1.0000). This reflects the linearity of the
HPLC-system within the calibration range of 0.080 pg/ml to 1.334 pg/ml of the test item.
In conclusion, the partition coefficient of ucb 22060 was determined to be
log Pow = -0.7
using the flask shaking method.
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