ucb 22060

Hydrolysis

Administrative data

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2003

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2003

Report date:

2003

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Results and discussion

Transformation products:

not measured

Dissipation DT50 of parent compound

Dissipation DT50 of parent compound 1

pH:

4

Temp.:

25 °C

DT50:

> 8 760 h

Dissipation DT50 of parent compound 2

pH:

7

Temp.:

25 °C

DT50:

> 8 760 h

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

According to the EEC Directive 92/69, Section C.7 it can be concluded, that the estimated
half-life time is higher than one year under representative environmental conditions (25”C).
Therefore, ucb 22060 was considered to be hydrolytically stable, and no further testing was
necessary.

Executive summary:

The hydrolysis determination of ucb 22060 at different pH values was based on the OECD Guideline No. 111, “Hydrolysis as a Function of pH”; adopted May 12, 1981 and on the EEC Directive 92/69, Section C.7, “Abiotic Degradation: Hydrolysis as a Function of pH”, L383 A, December 1992. The results of pH 4.0, pH 7.0 and pH 9.0 showed no significant degradation of ucb 22060 at 50°C. The degradation of ucb 22060 was less than 10 % after 5 days. The results are summarised in the table abov. pH Hydrolysis after 5 days, 50°C [%] 4.0