Registration Dossier
Registration Dossier
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EC number: 269-648-1 | CAS number: 68308-36-1 Meal resulting from solvent extraction of oil from soybeans.
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Soybean meal
- EC Number:
- 269-648-1
- EC Name:
- Soybean meal
- Cas Number:
- 68308-36-1
- IUPAC Name:
- 3-(4-hydroxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4H-chromen-4-one; 3-oxo-3-{[(2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-{[3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl]oxy}oxan-2-yl]methoxy}propanoic acid; 5,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one; 5-hydroxy-3-(4-hydroxyphenyl)-7-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4H-chromen-4-one; 7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one
Constituent 1
In vitro test system
- Test system:
- artificial membrane barrier model
- Vehicle:
- unchanged (no vehicle)
- Details on test system:
- The test system is composed of two components, a synthetic macromolecular barrier and a chemical detection system (CDS).
- Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- Amount/concentration applied:
- 500 mg
- Duration of treatment / exposure:
- up to 60 minutes
- Number of replicates:
- 4 replicates for the test item
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: breakthrough time (min)
- Run / experiment:
- mean
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- no indication of irritation
- Remarks:
- no breakthrough was noted with the test article after 60 minutes
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test article, Soybean meal, was considered to be non-corrosive according to the UN GHS classification system.
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