Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

There are no terrestrial data available for sodium p-chloro-m-cresolate (CAS 15733-22-9). Therefore, a read-across approach was conducted to compile relevant data from a structurally and chemically related source substance in order to fulfill the standard information requirements laid down in Annex VIII of REACH Regulation (EC) No 1907/2006. The read-across was conducted in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5.

This read-across is based on the hypothesis that the source substance (p-chloro-m-cresol, CAS 59-50-7) and the target substance (sodium p-chloro-m-cresolate) have similar respectively the same toxicological and eco-toxicological properties. The target substance is transformed by hydrolysis into the source substance and sodium cation. The source substance p-chloro-m-cresol is the common compound in this analogue approach and is solely responsible for the (absence of) effects. Thus, the source substance is considered a suitable representative for the evaluation of the toxicity of the target substance to terrestrial organisms. The read-across approach is justified in detail within the analogue justification in IUCLID section 13.

Acute and chronic tests evaluating the toxicity of p-chloro-m-cresol (CAS 59-50-7) to terrestrial organisms are available. The toxicity of the test item to earthworms was assessed in two studies the respective NOEC based on reproduction was determined to be 10 mg/kg soil dw. The toxicity to terrestrial plants was investigated in one long and one short-term study. The overall lowest NOEC was 100 mg/kg soil dw. The toxicity to soil macroorganisms and microorganisms was investigated in two studies. The EC50 was 555.1 mg/kg soil dw and the NOEC 300 mg/kg soil dw.

Based on the available results from a structurally similar source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is the main transformation product of the target substance and is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that sodium p-chloro-m-cresolate has effects in the same range as the target substance.