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EC number: 239-825-8 | CAS number: 15733-22-9
Table 2:Results of acute inhalationl toxicity testing
Target concentration [mg/L air]
Duration of clinical signs (days)
Time of death
Rectal temperature [°C]
0 - 9
0 - 12
0 - 8
0 - 14
*number of dead animals/ number of animals with signs/ number of animals used
** p < 0.01
A study for acute inhalation toxicity in the rat was conducted with the test substance according to the OECD Guideline 403 (1981) and in compliance with GLP.Five male and five female Wistar rats per dose group were nose-only exposed for 4 h to a solid aerosol (dust) of the test substance at target concentrations of 2 and 3 mg/L air. The analytical concentrations were 1.558 and 2.860 mg/L. The average dust concentrations reached were 1.337 mg/L and 2871 mg/L, which was the highest attainable aerosol concentration. 49% and 36.4% of the particles of the 2 and 3 mg/L group were smaller than 3 µm in aerodynamic diameter, respectively. Analysis of the aerosol particle-size distribution from the breathing zone samples demonstrates that the aerosol generated was within the respirable range. Detailed clinical observations were made several times on the day of exposure and at least once daily thereafter. Body weights were taken before exposure, on days 3 and 7, and weekly thereafter. Rectal temperatures were determined within 30 min after exposure and reflex-measurements were performed on the first post-exposure day. A complete gross pathological examination was conducted on each rat at the end of the 14 day post-exposure period. Exposure to the maximum technically attainable concentration of 2.871 mg/L did not result in mortality. The clinical signs observed were indicative of respiratory distress, associated with subdued demeanour, decreased body weights, emaciation, and hypothermia. In some rats the clinical signs lasted until the end of the 14 day post-exposure period. However, most rats showed evidence of recovery during the study period. Necropsy findings consisted of a less collapsed lung and secretions in the trachea. The hypothermia is considered to be related to upper respiratory irritation caused by the high concentrations of aerosol tested. According to the results, the test substance has an irritant potential to the respiratory tract, although it is of low acute inhalation toxicity to rats. Under the conditions of this study the LC50 value was considered to be > 2.871 mg/L for male and female rats corresponding to the highest attainable concentration. According to Regulation (EC) No 1272/2008 the test material does not need to be classified for acute inhalation toxicity.
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