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EC number: 239-825-8
CAS number: 15733-22-9
Table 1: Results of eye
Hours/days after application and rinsing
* area/degree of damage (area: 1 = ¼, 2 = ½, 3 = ¾, 4 = whole
region of cornea)
A study for eye irritation in the rabbit was conducted with the
test substance. The test substance (50 mg) was instilled into the
conjunctival sac of one male and one female New Zealand White rabbit.
Ocular reactions were scored at 1, 24, 48 and 72 h as well as 7 days
after test substance administration. The Draize system was used for
scoring eventual lesions. Cornea opacity (score 4) was noted in ½ of the
whole region of the cornea at all reading points after administration in
1/2 animal. With regard to the second animal, cornea opacity (score 4)
was observed in ¾ of the whole region while at 24, 48 and 72 h as well
as at 7 days after administration the whole region of the cornea was
affected (score 3). Iritis (score 1 – 2 in animal 1 and score 2 in
animal 2) was observed in both animals at every observation. Redness of
the conjunctivae was noted in both animals at 1, 24, 48, 72 h and 7 days
(score 1 – 3). Swelling of the conjunctivae (score 1 – 3) was also noted
through the whole observation period. Thus, under the conditions of this
study, the test substance causes severe damages to the eyes, which in
terms of classification according to Regulation (EC) No 1272/2008
implies classification as Eye Dam. 1, H318: Causes serious eye damage.
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