Registration Dossier
Registration Dossier
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EC number: 220-518-2 | CAS number: 2788-26-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
- Principles of method if other than guideline:
- A dose of 100 µl Phosphono succinic acid tetramethylester was administered into one eye of two young adult New Zealand white rabbits (3–4 kg) for an exposure period of 24 hours. Then the treated eyes were rinsed with sterile water. The contralateral eye remained untreated and served as a control. The eyes were examined and the grade of ocular reaction was recorded until day 7 post administration according to Draize.
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethyl (dimethoxyphosphinyl)succinate
- EC Number:
- 220-518-2
- EC Name:
- Dimethyl (dimethoxyphosphinyl)succinate
- Cas Number:
- 2788-26-3
- Molecular formula:
- C8H15O7P
- IUPAC Name:
- 1,4-dimethyl 2-(dimethoxyphosphoryl)butanedioate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- 100 µl
- Duration of treatment / exposure:
- After the exposure period of 24 hours the treated eyes were rinsed with sterile water.
- Observation period (in vivo):
- Seven days.
- Number of animals or in vitro replicates:
- Two animals.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: score = 0 at any time point
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: score = 0 at any time point
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Max. score:
- 3
- Reversibility:
- fully reversible within: 3 days
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: score = 0 at any time point
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The mean cornea, iris and chemosis score was 0 at 24/48/72 hours.The mean conjunctivae was 0.66 at 24/48/72 hours; it was fully reversible within 3 days.
- Executive summary:
A dose of 100 µl Phosphono succinic acid tetramethylesterwas administered into one eye of two young adult New Zealand white rabbits (3–4 kg) for an exposure period of 24 hours. Then the treated eyes were rinsed with sterile water. The contralateral eye remained untreated and served as a control. The eyes were examined and the grade of ocular reaction was recorded until day 7 post administration according to Draize. The mean cornea, iris and chemosis score was 0 at 24/48/72 hours.The mean conjunctivae score was 0.66 at 24/48/72 hours; it was fully reversible within 3 days.
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