Registration Dossier
Registration Dossier
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EC number: 220-518-2 | CAS number: 2788-26-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
- Principles of method if other than guideline:
- 500 µl Phosphono succinic acid tetramethylester were semiocclusively applied once to the intact skin (ear) of two young adult New Zealand white rabbits (3.0–4.0 kg) for an exposure period of 24 hours. Evaluation of skin irritation was made until day 7 according to Draize.
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethyl (dimethoxyphosphinyl)succinate
- EC Number:
- 220-518-2
- EC Name:
- Dimethyl (dimethoxyphosphinyl)succinate
- Cas Number:
- 2788-26-3
- Molecular formula:
- C8H15O7P
- IUPAC Name:
- 1,4-dimethyl 2-(dimethoxyphosphoryl)butanedioate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 500 µl
- Duration of treatment / exposure:
- 24 houts
- Observation period:
- 7 days
- Number of animals:
- 2 rabbits
- Details on study design:
- After 24 hours the test material was removed with water and soap.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: score = 0 at any time point
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: score = 0 at any time point
- Irritant / corrosive response data:
- not irritant
- Other effects:
- No other effects reported.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance proved to be not irritating.
- Executive summary:
500 µl Phosphono succinic acid tetramethylester were semiocclusively applied once to the intact skin (ear) of two young adult New Zealand white rabbits (3.0–4.0 kg) for an exposure period of 24 hours. Evaluation of skin irritation was made until day 7 according to Draize. Erythema and edema score = 0 at 24/48/72 hours. The test substance proved to be not irritating.
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