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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Principles of method if other than guideline:
One group of five male and five female Wistar rats were dosed at 5.0 ml/kg. The animals were observed for mortality and clinical signs through day 14. The surviving animals were randomly dissected.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl (dimethoxyphosphinyl)succinate
EC Number:
220-518-2
EC Name:
Dimethyl (dimethoxyphosphinyl)succinate
Cas Number:
2788-26-3
Molecular formula:
C8H15O7P
IUPAC Name:
1,4-dimethyl 2-(dimethoxyphosphoryl)butanedioate

Test animals

Species:
rat
Strain:
Wistar
Details on test animals or test system and environmental conditions:
At the start of the study the rats were approx. 9 respective 14 weeks old. The average weight of the male rats was 151 g, and the average weight of the female rats was 159 g.
The rats were kept in Macrolon typ III cages at a temperature of 22 +/- 1.5°C. Air humidity was 60 +/- 5% at artifical light for 12 hours daily. Water was ad libitum.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
About 16 hours before the application and 4 hours afterwards feed was restricted.
Doses:
5 ml/kg bw = 3942 mg/kg bw.
No. of animals per sex per dose:
5 male and 5 female rats per dose
Control animals:
no
Details on study design:
The animals killed at the end of the study were randomly dissected.

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
discriminating dose
Effect level:
5 mL/kg bw
Based on:
test mat.
Remarks on result:
other: 5 ml/kg bw = 3942 mg/kg bw.
Mortality:
No mortality occured.
Clinical signs:
other: No clinical signs were observed.
Gross pathology:
No adverse findings.
Other findings:
No data.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
A single dose of 5 ml/kg bw = 3942 mg/kg bw was tolerated without symptoms.
Executive summary:

One group of five male and five female Wistar rats were dosed at 5.0 ml/kg. The animals were observed for mortality, and clinical signs through day 14. The surviving animals were randomly dissected. A single dose of 5 ml/kg bw = 3942 mg/kg bw was tolerated without symptoms. No mortality occured.