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Vapour pressure

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Endpoint:
vapour pressure
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Study period:
2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
Justification for type of information:
QSAR prediction

1. SOFTWARE
Danish (Q)SAR Database

2. MODEL
http://qsardb.food.dtu.dk/db/index.html

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
C(=O)(O)C(CCC(=O)O)NC(=O)CCCCCCCC=CCCCCCCCC

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
http://qsardb.food.dtu.dk/db/index.html

5. APPLICABILITY DOMAIN
http://qsardb.food.dtu.dk/Danish_QSAR_Database_Draft_User_manual.pdf

6. ADEQUACY OF THE RESULT
Prediction fits the purpose of REACH Regulation.
Guideline:
other: REACH GUIDANCE ON QSARs R6, May 2008
GLP compliance:
no
Key result
Test no.:
#1
Vapour pressure:
ca. 0 mm Hg
Remarks on result:
other: Qsar Prediction
Remarks:
Qsar Prediction
Key result
Test no.:
#2
Vapour pressure:
ca. 0 Pa
Remarks on result:
other: Qsar Prediction
Remarks:
Qsar Prediction
Conclusions:
The vapour pressure of the test item is:
- 1.54E-013 (mm Hg)
- 2.053E-011 (Pa)
Executive summary:

Vapour pressure of the substance is low.

Endpoint:
vapour pressure
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data are being assessed for the use in a category approach. Available information are being judged as reliable with restrictions since it was conducted by a modeled and measured data.
Remarks:
Data are being assessed for the use in a category approach. Available information are being judged as reliable with restrictions since it was conducted by a modeled and measured data.
Justification for type of information:
Modeled and measured data

Important considerations for the read-across were:

Sodium Olivoyl Glutamate (the target chemical) has similar physico-chemical properties as the others members:
- "Aliphatic acid category" (the source chemicals);
- "Amino acid alkyl amides category" (the source chemicals);
- Sodium oleoyl glutamate (the source chemicals);

Key points are that the members share:
- the same structural features
- similar metabolic pathways
- common levels and mode of human health related effects
- function.
Qualifier:
no guideline available
GLP compliance:
no
Key result
Test no.:
#1
Vapour pressure:
ca. 0 Pa
Conclusions:
Vapour pressure is:
- C8 6.51E-09 -
- C18 1.35E-12
- C18:1 1.68E-12
- C18:2 8.01E-13 (modeled)
Executive summary:

Vapour pressure is low.

Description of key information

A collection of the vapour pressure values was performed. Since values are extremely low, the vapor pressure was deemed to be a negligible properties.

The substance have negligible vapour pressures.

Key value for chemical safety assessment

Vapour pressure:
0 Pa

Additional information

Overall, considering available data on the category members the substance have a negligible vapour pressures.