Glutamic acid, N-olivoyl derivs., sodium salts

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data are being assessed for the use in a category approach. Available information are being judged as reliable with restrictions since it was conducted by a modeled and measured data.

Remarks:

Data are being assessed for the use in a category approach. Available information are being judged as reliable with restrictions since it was conducted by a modeled and measured data.

Justification for type of information:

Important considerations for the read-across were:

Sodium Olivoyl Glutamate (the target chemical) has similar physico-chemical properties as the others members:
- "Aliphatic acid category" (the source chemicals);
- "Amino acid alkyl amides category" (the source chemicals);
- Sodium oleoyl glutamate (the source chemicals);

Key points are that the members share:
- the same structural features
- similar metabolic pathways
- common levels and mode of human health related effects
- function.

Data source

Reference

Reference Type:

publication

Title:

OECD SIDS ALIPHATIC ACIDS CATEGORY

Author:

SIDS Initial Assessment Report

Year:

2014

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

category data of Aliphatic acids category

GLP compliance:

not specified

Test material

Test material information

1

Reference substance name:

not applicable

Molecular formula:

not applicable

IUPAC Name:

not applicable

Specific details on test material used for the study:

not specified

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

not specified

Details on test solutions:

not specified

Test organisms

Test organisms (species):

other: not specified

Details on test organisms:

not specified

Results and discussion

Effect concentrations

Key result

Dose descriptor:

other: See data available for category substances

Remarks:

See data available for category substances

Conc. based on:

other: See data available for category substances

Basis for effect:

other: See data available for category substances

Remarks:

See data available for category substances

Remarks on result:

other: See data available for category substances

Remarks:

See data available for category substances

Details on results:

There were no acute effects on aquatic invertebrates or algae with LC50 values exceeding either the water solubility of the substance or were greater than 100 mg/L. Two exceptions included sponsored substance, Fatty acids, C12-18, sodium salts (CAS 91032-12-1) and supporting substance, Hexadecanoic acid (CAS No 124-04-9), with algae EC50 values between 1 and 100 mg/L. No acute aquatic toxicity data were located for magnesium and calcium or ammonium aliphatic acid substances.

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The Aliphatic Acids category members possess properties indicating a hazard for the environment (acute toxicity to aquatic organisms between 1-100 mg/L for C6, and C12-18 sodium salts). Aliphatic Acids category members are readily biodegradable and are not expected to bioaccumulate.

The substance deemed to be non-toxic.

Executive summary:

The substance deemed to be non-toxic.