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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation, other
Remarks:
in vitro and in vivo studies
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Important considerations for the read-across were:

Sodium Olivoyl Glutamate (the target chemical) has similar physico-chemical properties as the others members:
- "Aliphatic acid category" (the source chemicals);
- "Amino acid alkyl amides category" (the source chemicals);
- Sodium oleoyl glutamate (the source chemicals);

Key points are that the members share:
- the same structural features
- similar metabolic pathways
- common levels and mode of human health related effects
- function.

Data source

Reference
Reference Type:
publication
Title:
OECD SIDS ALIPHATIC ACIDS CATEGORY
Author:
SIDS Initial Assessment Report
Year:
2014

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Data available is referred to aliphatic acids category.
GLP compliance:
not specified

Test material

1
Reference substance name:
not applicable
Molecular formula:
not applicable
IUPAC Name:
not applicable
Specific details on test material used for the study:
not specified

Test animals / tissue source

Species:
other: not specified
Strain:
not specified
Remarks:
not specified
Details on test animals or tissues and environmental conditions:
not specified

Test system

Vehicle:
not specified
Amount / concentration applied:
not specified
Duration of treatment / exposure:
not specified
Observation period (in vivo):
not specified
Duration of post- treatment incubation (in vitro):
not specified
Number of animals or in vitro replicates:
not specified
Details on study design:
not specified

Results and discussion

In vitro

Results
Irritation parameter:
other: See conclusion
Run / experiment:
See conclusion
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: See conclusion
Other effects / acceptance of results:
See conclusion

In vivo

Results
Irritation parameter:
other: See conclusion
Basis:
other: See conclusion
Time point:
other: See conclusion
Reversibility:
other: See conclusion
Remarks on result:
other: See conclusion
Irritant / corrosive response data:
See conclusion
Other effects:
See conclusion

Any other information on results incl. tables

See conclusion

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
No ocular irritation was observed in in vitro studies of acetyl tyrosine (up to 1.25%), disodium capryloyl glutamate (up to 2%), and sodium lauroyl glutamate (up to 5%). Severe irritation was observed with sodium cocoyl glutamate at 5% using the hen’s egg test chorioallantoic membrane (HET-CAM) method, but it was not irritating in another study with an unknown concentration. Slight irritation was observed with sodium lauroyl silk amino acids at 0.5% using the HETCAM method. Lauroyl arginine in a mixture at 10% was not irritating to rabbit eyes. No adverse effects were observed during in-use studies of eye-area products containing acetyl hydroxyproline (up to 2%) and acetyl tyrosine (up to 2%) in human participants.
Executive summary:

Slight irritation was observed with sodium lauroyl silk amino acids at 0.5% using the HETCAM method.