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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
yes
Remarks:
Short equilibration times were used, because of the fast decomposition of the test item.
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2014
Deviations:
yes
Remarks:
Short equilibration times were used, because of the fast decomposition of the test item.
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Version / remarks:
1998
Deviations:
yes
Remarks:
Short equilibration times were used, because of the fast decomposition of the test item.
Principles of method if other than guideline:
Because of the fast decomposition of the test item the saturation mass concentration cannot be achieved. Therefore the shake-flask method was performed applying shortened equilibration period.
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
185 mg/L
Conc. based on:
test mat.
Loading of aqueous phase:
1 g/L
Incubation duration:
90 min
Temp.:
20 °C
pH:
3.4
Details on results:
The calibration solutions were prepared in the 0.2 - 30 μg/mL concentration range and analysed by HPLC with three replicate injections.
The determined concentration of the test item in water first increased from 174 to 185 mg/L with the shaking period from 15 to 90 minutes and then declined until 180 min to 167 mg/L.
Based on the above data the water solubility of the test item is 0.2 g/L.
Conclusions:
The water solubility of the test item is 0.2 g/L at 20 °C.
Executive summary:

The water solubility of the test item was determined at 20 °C ± 1 °C using the shake-flask method and analysis by HPLC.

Short equilibration times were used, because of the fast decomposition of the test item. Highest concentration of the test item was measured after 90 minutes shaking. The concentration measured at this time point, 0.2 g/L is considered to be the estimated water solubility of 7-ACT.

Description of key information

The water solubility of the test item is 0.2 g/L at 20 °C.

Key value for chemical safety assessment

Water solubility:
200 mg/L
at the temperature of:
20 °C

Additional information