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EC number: 948-065-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- no hazard identified
Marine water
- Hazard assessment conclusion:
- no hazard identified
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 27 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- no hazard identified
Sediment (marine water)
- Hazard assessment conclusion:
- no hazard identified
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no hazard identified
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
The test item is ‘readily biodegradable’ (10-day window not applicable to multi-constituent substances consisting of structurally similar constituents (OECD, 2006)).
The test item has a measured log Kow < 4.0 (consequential Bioconcentration Factor (BCF) is considered < 500 L/wt)
The test item does not indicate EC50/LC50 < 100 mg/L or EC10 (algae) or relevant NOEC in available studies as < 1 mg/L.
Relevant data available for aquatic toxicity are listed:
1. 48-h EC50 (invertebrates) : > 100 mg/L based on analytically confirmed nominal concentrations, freshwater, OECD TG 202, 2021
2. Read-Across: source data : Reaction products of 2-hydroxyethyl methacrylate and diphosphorus pentaoxide :
72-h ErC50 (aquatic algae; growth rate): = 165 mg/L based on TWA concentrations, 72 hour, freshwater, OECD TG 201, 2004
72-h NOErC (algae; growth rate): = 39 mg/L based on TWA concentrations, 72 hour, freshwater, OECD TG 201, 2004
Therefore:
72-h ErC50 (aquatic algae; growth rate): target : > 100 mg/L (or 165 mg/L) based on TWA concentrations, 72 hour, freshwater, OECD TG 201, 2021
72-h ErC10 (algae; growth rate) : target : > 39 mg/L based on TWA concentrations, 72 hour, freshwater, OECD TG 201, 2021
72-h NOErC (algae; growth rate): target : = 39 mg/L based on TWA concentrations, 72 hour, freshwater, OECD TG 201, 2021
3. Read-Across: source data : Reaction products of 2-hydroxyethyl methacrylate and diphosphorus pentaoxide :
96-h LC50 (fish) : > 100 mg/L based on analytically confirmed nominal concentrations, OECD TG 203, 2004
Therefore:
96-h LC50 (fish) : target : > 100 mg/L based on analytically confirmed nominal concentrations, freshwater, OECD TG 203, 2021
4. ASRIT:
Total Respiration Inhibition:
3h-EC50 = > 270 mg/L (nominal), 20 °C
3h-EC10 = - mg/L (nominal), 20°C
NOEC = 270 mg/L(nominal), 20 °C, OECD TG 209, 2021
Heterotrophic Respiration Inhibition:
3h-EC50 = > 270 mg/L (nominal), 20 °C
3h-EC10 = - mg/L (nominal), 20 °C
NOEC = 270 mg/L(nominal), 20 °C, OECD TG 209, 2021
Nitrification Inhibition:
3h-EC50 = > 810 mg/L (nominal), 20 °C
3h-EC10 = - mg/L (nominal), 20 °C
NOEC = 810 mg/L(nominal), 20 °C, OECD TG 209, 2021
5. Biodegradation: readily biodegradable, mean biodegradation 77% (28-days). 10 -day window not applicable to multi-constituent/UVCB substances consisting of structurally similar constituents (OECD, 2006); OECD TG 301B, 2018
6. log Pow (HPLC) : OECD TG 117, 2021
(i) at 35 °C pH 2: log Pow range = ≥ -0.8 to ≤ 2.8 ; with six peaks (two coeluting), respective log Pow: -0.8, 0.6 (coelution of two peaks), 2.3, 2.4 and 2.8
peak at log Pow - 0.8 (extrapolated) as beyond lower limit of calibration range: log Pow = 0.3 to 4.2
(ii) at 35 °C buffered pH 7: ≥ -2.0 to ≤ 2.8 ; with six peaks, and two eluting beyond the lower calibration range, respective log Pow: -2.0, 2.3, 2.4 and 2.8
peak at log Pow – 2.0 (extrapolated) as beyond lower limit of calibration range: log Pow = 0.3 to 4.2
The HPLC screening test confirms no constituents are expected to have a log Pow > 3.0 at pH 4, pH 7 or pH 9.
It can be considered that the test item consists of blocks of components that range from extremely low log Pow to low Pow at pH 4 to pH 7:
Block 3: log Pow = -2.0 to 0.6 (highly water soluble/essentially ‘miscible’, > 10000 mg/L)
Block 2: log Pow = 0.6 to 2.0 (water soluble, > 1000 mg/L)
Block 1: log Pow 2.1 to 2.8 (slightly soluble, 1 – 100 mg/L)
Supporting information:
Calculated log Kow (range): -1.7179 to 2.1995 in three blocks, respectively, at 25 °C; ca. pH 7, QSAR Prediction - KOWWIN v1.68, 2018
The majority of constituents had Log Kow = -0.7490 to 1.0627 and no constituents have predictions for Log Kow > 4.0.
Degradation references:
1. Introduction to the section of the OECD Guidelines for Testing of Chemicals on Degradation and Accumulation, Section 3 (OECD, September 2006)
2. ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7b: Endpoint Specific Guidance, R.7.9.4, June 2017)
3. ECHA Guidance on Application on the CLP Criteria, section 4.1.3.2.3.2 (v5.0, July 2017)
4. GHS revision 4 (2011), Globally Harmonized System of Classification and Labelling of Chemicals (GHS). Chapter 4.1. Hazardous to the aquatic Environment. United Nations
5. Sub-Committee of Experts on the Globally Harmonized System of Classification and Labelling of Chemicals (2008). Updating of the second revised edition of the globally harmonized system of classification and labelling of chemicals (GHS) : 10-Day window: Technical support document to ST/SG/AC.10/CA/2008/27 UN/SCEGHS/16/INF.17
Conclusion on classification
The substance does not meet classification criteria under Regulation (EC) No 1272/2008 as hazardous to the aquatic environment.
The test item is ‘readily biodegradable’ (10-day window not applicable to multi-constituent substances consisting of structurally similar constituents (OECD, 2006)).
The test item has a measured log Kow < 4.0 (consequential Bioconcentration Factor (BCF) is considered < 500 L/wt)
The test item does not indicate EC50/LC50 < 100 mg/L or EC10 (algae) or relevant NOEC in available studies as < 1 mg/L.
References:
1. ECHA Guidance on Application on the CLP Criteria, (v5.0, July 2017)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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