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EC number: 217-123-2 | CAS number: 1746-03-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April - July 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- Adopted: 04. April 1984
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Directive 79/831 Annex V
- Version / remarks:
- Methods for the Determination of Ecotoxicity 5.1.2 Acute Toxicity for Daphnia Stand Mai 1984
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Homogenization with Ultra-Turrax and ultrasonic bath - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Waterflea
- Strain/clone: STRAUS
- Source: Stock-culture of the Department of Toxicology (Hoechst AG)
- Age of parental stock: max 42 days
- Feeding during test: no - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 21.3 - 22.0
- pH:
- 8.2 - 8.3
- Dissolved oxygen:
- 8.2 - 9.4 mg/L
- Nominal and measured concentrations:
- Nominal concentrations: 560, 1000 mg/L
Measured concentrations: 1003.2 mg/L (only the control and the highest concentration were analytically determined) - Details on test conditions:
- TEST SYSTEM
- Test vessel: 250 mL glass beakers
- Material, size, fill volume: glass, hight 110mm diameter 70mm, 200 mL
- Aeration: yes
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Preparation of dilution water: Elendt Medium with desalinated water
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Adjustment of pH: yes, with 0.18 - 0.28 ml 10 molar NaOH
- Light: fluorescent tubes in a day/night cycle, with each period lasting 12 hours
EFFECT PARAMETERS MEASURED :
After 24 and 48 hours: inspection for immobility and recording of water parameters
RANGE-FINDING STUDY
yes, but no details available - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: no
- Observations on body length and weight: no
- Other biological observations: no
- Mortality of control: no
- Other adverse effects control: no
- Abnormal responses: no
- Any observations that might cause a difference between measured and nominal values: no
- Effect concentrations exceeding solubility of substance in test medium: no - Validity criteria fulfilled:
- yes
- Conclusions:
- The 48-h acute toxicity test to Daphnia magna revealed a nominal EC0 value of 1000 mg/L and an EC100 and EC50 value of >1000 mg/L after 48 hours.
- Executive summary:
The 48-h acute toxicity of the test item to Daphnia magna was studied under static conditions according to OECD 202 (1984) and EEC Directive 79/831 (1984). Daphnids were exposed to the test item at nominal concentrations of 560 and 1000 mg/L. An analytical monitoring was performed. To produce the stock solution the test substance was weighed into water and homogenized with Ultra-Turrax and ultrasonic bath. During the study the dissolved oxygen, pH, water temperature and the immobilization rate were measured. Based on the number of immobile daphnids the EC values were determined. The EC0 value was 1000 mg/L (measured) and the EC100 was > 1000 mg/L (measured). The EC50 value was determined to be >1000 mg/L.
Reference
Sampling date |
1992-07-09 |
1992-07-11 |
Geometric mean measured concentration [mg/L] |
||
Nominal concentration |
Meas. conc. [mg/L] |
% |
Meas. conc. [mg/L] |
% |
|
Control |
<LOQ |
|
<LOQ |
|
|
1000 mg/L |
999.3 |
99.93 |
1007 |
100.7 |
1003.15 |
Meas. conc. = Measured concentration of the test item, enrichment and dilution factor taken into account
% = Percent of nominal concentration of test item
LOQ = Limit of Quantification (0.1 mg/L test item)
Description of key information
The 48-h acute toxicity test to Daphnia magna revealed a nominal EC0 value of 1000 mg/L and an EC100 and EC50 value of >1000 mg/L after 48 hours.
Key value for chemical safety assessment
Additional information
The 48-h acute toxicity of the test item to Daphnia magna was studied under static conditions according to OECD 202 (1984) and EEC Directive 79/831 (1984). Daphnids were exposed to the test item at nominal concentrations of 560 and 1000 mg/L. An analytical monitoring was performed. To produce the stock solution the test substance was weighed into water and homogenized with Ultra-Turrax and ultrasonic bath. During the study the dissolved oxygen, pH, water temperature and the immobilization rate were measured. Based on the number of immobile daphnids the EC values were determined. The EC0 value was 1000 mg/L (measured) and the EC100 was > 1000 mg/L (measured). The EC50 value was determined to be >1000 mg/L.
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