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EC number: 217-123-2 | CAS number: 1746-03-8
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2017-01-24 to 2017-08-31
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: Knudsen cell
- Specific details on test material used for the study:
- Batch No.: VPS9016001
Purity: 97.3 % - Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0 Pa
- Temp.:
- 25 °C
- Vapour pressure:
- 0 Pa
- Conclusions:
- The vapour pressure of the test item was estimated to be 3.15E-5 Pa at 20 °C and 5.39E-5 Pa at 25 °C, respectively.
- Executive summary:
A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item. The vapour pressure of the test item was determined at temperatures between 30 and 150 °C using the effusion method (Knudsen cell). For the evaluation the vapour pressure values at temperatures of 90, 105 and 120 °C were used. The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20 and 25 °C. The vapour pressure was calculated to be 3.15E-5 Pa at 20 °C and 5.39E-5 Pa at 25 °C, respectively.
Reference
Experiments with nominal temperature 30 – 75 and 135 - 150 °C showed no reproducible or relevant mass loss. Therefore, the experimental results at temperatures 90, 105 and 120 °C were used for evaluation.
Table 1. Experimentally Determined Vapour Pressures
T |
T |
P |
Stand. Dev. P |
RSD P |
°C |
K |
Pa |
Pa |
% |
90.0 |
363.2 |
1.39E-02 |
1.14E-03 |
8.2% |
105.0 |
378.2 |
4.74E-02 |
5.69E-03 |
12.0% |
120.0 |
393.2 |
9.89E-02 |
2.78E-02 |
28.1% |
For the test item, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:
Vapour pressure at 20 °C: |
3.15 * 1E-5Pa |
Vapour pressure at 25 °C: |
5.39 * 1E-5 Pa |
The vapour pressure of the test item was determined at nine different temperatures (30, 45, 60, 75, 90, 105,120, 135 and 150 °C) following EU A.4 using the effusion method (weight loss). Experiment 1 – 4 and 8 - 9 (nominal temperature 30 - 75 and 135 - 150 °C) showed no reproducible weight loss. Three experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed sufficient reproducibility, giving relative standard deviations of less than 29 % and good correlation.
Description of key information
The vapour pressure of the test item was estimated to be 3.15E-5 Pa at 20 °C and 5.39E-5 Pa at 25 °C, respectively.
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 20 °C
Additional information
A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item. The vapour pressure of the test item was determined at temperatures between 30 and 150 °C using the effusion method (Knudsen cell). For the evaluation the vapour pressure values at temperatures of 90, 105 and 120 °C were used. The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20 and 25 °C. The vapour pressure was calculated to be 3.15E-5 Pa at 20 °C and 5.39E-5 Pa at 25 °C, respectively.
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