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Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2017-10-02 to 2017-11-20
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
capillary method
Specific details on test material used for the study:
Batch No.: VPS9016001
Purity: 97.3 %
Key result
Melting / freezing pt.:
38.5 °C
Atm. press.:
1 013 hPa
Decomposition:
no
Sublimation:
no

During the preliminary test using a linear heating rate of 10 °C/min the phase transition of test item was observed at 39 °C.

In the main test using a linear heating rate of 0.5 °C/min the melting point of the test item was determined to be 38.5 °C (311.6 K).

Table 1.Measured temperatures corresponding to the melting point of Test Item (two experiments (I, II) with three parallel samples each (1, 2, 3))

Sample

Temperature (°C)

Mean (°C)

Standard Deviation

Confidence interval (95 %)

I /1

39.0

38.5

0.54

0.57

I /2

38.6

I /3

37.9

II /1

38.5

II /2

39.1

II /3

37.8
Conclusions:
The melting point of the test item was determined to be 38.5 °C.
Executive summary:

A study was conducted according to OECD TG 102, Regulation (EC) No. 440/2008 method A.1 and EPA OPPTS 830.7200 to determine the melting point of the test item using the capillary method. In a preliminary test using a linear heating rate of 10 °C/min the phase transition of the test item was observed at 39 °C. For the main test, a small amount of test item was charged in capillary glass tubes and packed tightly to obtain a filling level of approximately 5 mm. Three capillaries were prepared.Heating was started from 25 °C.Using linear heating rate of 0.5 °C/min, the melting point of the test item was determined to be 38.5 °C at 1013.25 hPa.

Description of key information

The melting point of the test item was determined to be 38.5 °C.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
38.5 °C

Additional information

A study was conducted according to OECD TG 102, Regulation (EC) No. 440/2008 method A.1 and EPA OPPTS 830.7200 to determine the melting point of the test item using the capillary method. In a preliminary test using a linear heating rate of 10 °C/min the phase transition of the test item was observed at 39 °C. For the main test, a small amount of test item was charged in capillary glass tubes and packed tightly to obtain a filling level of approximately 5 mm. Three capillaries were prepared. Heating was started from 25 °C. Using linear heating rate of 0.5 °C/min, the melting point of the test item was determined to be 38.5 °C at 1013.25 hPa.