Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From November 16, 2016 to December 22, 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report Date:
2016

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid: viscous
Specific details on test material used for the study:
Aspect : clear, nearly colourless to lightly-yellow, highly viscous liquid

- Sample tested
Lot No. : 75518
Purity : 95.7%
Expiration date : September 19, 2018

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
0.3
Temp.:
35 °C
pH:
7

Applicant's summary and conclusion

Conclusions:
In the conditions of the test, the chromatograms of Panthenyltriacetate show one peak at average retention times of 2.437 minutes, corresponding to a partition coefficient (log value) of 0.3.

Therefore:
Partition coefficient n-octanol/water of Panthenyltriacetate:
log Pow = 0.3*

* Peak outside the calibration range

N.B.: The determination was performed at 35°C (temperature of the column), but the value obtained above can be considered to represent the value at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log Pow values were determined. Partition coefficients of the test and reference substances are assumed to vary with temperature in the same way.