Registration Dossier
Registration Dossier
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EC number: 269-495-0 | CAS number: 68258-72-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the water solubility limit.
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity of 2,2-bis(hydroxymethyl)propane-1,3-diyl didocosanoate (CAS 68258-72-0) to aquatic invertebrates are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance Fatty acids, C16-18 and C18-unsatd., tetraesters with pentaerythritol (CAS 68604-44-4) was conducted. The source substance is representative to evaluate the short-term toxicity of the target substance to aquatic algae.
The target substance 2,2-bis(hydroxymethyl)propane-1,3-diyl didocosanoate (CAS 68258-72-0) is characterized di-, tri-, tetraester of pentaerythritol an fatty acids with a chain lengths of C22. The degree of esterification is variable. However, mainly tri- and tetraesters are the result of the esterification process. Source substance Fatty acids, C16-18 and C18-unsatd., tetraesters with pentaerythritol (CAS 68604-44-4) is characterised as a tetraester of pentaerythritol with mainly C18 unsaturated fatty acids. This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
One study investigating the toxicity of the source substance fatty acids, C16-18 and C18-unsatd., tetraesters with pentaerythritol (CAS 68604-44-4) to aquatic algae and cyanobacteria is available (Junghans, 2010). The limit test was performed according to OECD 201. The green algae Desmodesmus subspicatus was exposed to a loading rate of 100 mg/L. The test solution was prepared by adding the appropriate amount of test substance with subsequent stirring followed by filtration. No effect on growth rate and biomass of Desmodesmus subspicatus up to the limit of water solubility was observed resulting in an EL50 (72 h) > 100 mg/L (nominal) and a NOELR (72 h) of ≥ 100 mg/L (nominal).
Based on the available result from a structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that 2,2-bis(hydroxymethyl)propane-1,3-diyl didocosanoate will not exhibit effects to aquatic algae up to the limit of water solubility.
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