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Cyclomaltodextrin glucanotransferase was not tested for aquatic toxicity, however, another enzyme - alpha-amylase - was chosen for read-across due to sensitivity to aquatic organisms.


- The 48-h EC50 value for alpha-amylase with Daphnia magna was 2000 mg test material/L corresponding to 212 mg active enzyme protein/L.


- Alpha-amylase was inhibitory to the growth of Desmodesmus subspicatus at concentrations in excess of 12.5 mg/L corresponding to 1.3 mg active enzyme protein (aep)/mL. The EbC50 (72h) value is 24 mg/L and the ErC50 (24-72h) is 49 mg/L corresponding to 2.5 and 5.2 mg aep/L, respectively.

Due to the similarity between enzymes, similar results are expected for cyclomaltodextrin glucanotransferase.

Additional information