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EC number: 618-522-8
CAS number: 9030-09-5
Some statistical significance in reverant colonies was attained for
TA100 in the presence of S-9 mix for the 3 highest concentration in
experiment 1, however, this was not reproducible in experiment 2.
CGTase, batch PPA 4357 was examined for mutagenic activity using Salmonella
typhimurium strain TA1535, TA100, TA1537 and TA98. A liquid culture
assay was applied. Bacteria were exposed to 6 doses of the test
substance up to 10000 μg/mL in a phosphate buffered nutrient broth for 3
hours. After incubation, the test substance was removed by
centrifugation prior to plating. The number of revertants to prototrophy
and viable cells were estimated. The test was conducted in the presence
and absence of metabolic activation - a liver preparation from male
rats, pre-treated with Aroclor 1254, and the co-factors required for
mixed function oxidase activity (S-9 mix). The sensitivity of the
individual bacterial strains was confirmed by significant increases in
number of revertant colonies induced in similar conditions by diagnostic
mutagens. All results were confirmed by conducting two independent
No dose-related and reproducible increases in revertants to prototrophy
were obtained with any of the bacterial strains exposed to CGTase,
either in the presence or absence of S-9 mix. It was concluded, that the
results of the experiments, described in this report, give no indication
of mutagenic activity of CGTase, batch PPA 4357 in the presence or
absence of metabolic activation.
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