Registration Dossier
Registration Dossier
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EC number: 212-266-7 | CAS number: 774-55-0
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 28 Aug 2017 to 22 Sep 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- 1-(5,6,7,8-tetrahydro-2-naphthyl)ethan-1-one
- EC Number:
- 212-266-7
- EC Name:
- 1-(5,6,7,8-tetrahydro-2-naphthyl)ethan-1-one
- Cas Number:
- 774-55-0
- Molecular formula:
- C12H14O
- IUPAC Name:
- 1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethan-1-one
- Test material form:
- liquid
- Details on test material:
- Appearance: Colourless to pale yellow liquid
Constituent 1
- Specific details on test material used for the study:
- Physical appearance: colourless to pale yellow liquid
Storage conditions: at room temperature protected from light, container flushed with nitrogen.
Results and discussion
Water solubility
- Key result
- Water solubility:
- 0.102 g/L
- Incubation duration:
- >= 24 - <= 72 h
- Temp.:
- 20 °C
- pH:
- 6.9
- Details on results:
- -Concentration analysed after 24, 48 and 72 hours of stirring: 0.0979 g/L, 0.105 g/L and 0.105 g/L, resp.
-Maximum difference meets the criterion of ≤ 15% (i.e. 6.9%)
-The mean of the three concentrations was reported as the water solubility of the substance.
Applicant's summary and conclusion
- Conclusions:
- The water solubility of the substance at 20°C was determined to be 0.102 g/L.
- Executive summary:
The water solubility of the substance was determined using the flask method in a GLP study according to EC A.6, OECD 105 and OPPTS 830.7840. Quantification was performed by UPLC-UV. The pH of the aqueous samples was 6.9. From the measurements obtained after 24, 48 and 72 hours of stirring, the water solubility at 20°C was determined to be 0.102 g/L.
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