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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://www.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- no hazard identified
Marine water
- Hazard assessment conclusion:
- no hazard identified
STP
- Hazard assessment conclusion:
- no hazard identified
Sediment (freshwater)
- Hazard assessment conclusion:
- no hazard identified
Sediment (marine water)
- Hazard assessment conclusion:
- no hazard identified
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no exposure of soil expected
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
The available data fromfreshwater ecotoxicity studies on Daphnia (Harlan 2011), fish (Harlan 2011) and algal growth (Harlan 2012) for Diurea 8 in a grease base and for algal growth for the isolated Diurea 8 thickener (Harlan 2012)showed no effects at up to 100 mg/L loading rate. In accordance with REACH Chapter R7b (ECHA 2012), PNECs have not been derived for freshwater, marine or intermittent release as the substances were tested as water accommodated fractions.
Diurea 8 shows no toxicity at the limit of water solubility, exhibits very low predicted vapour pressure values and is not applied directly to soil. Diurea 8 only occurs in a grease designed to minimise leaching and is not expected to be available in the aquatic environment for adsorption or bioaccumulation. As such, the STP, sediment, soil, secondary poisoning and air PNECs were not derived due to a lack of potential exposure or a lack of identified hazard.
Reference
ECHA (2012) Guidance on information requirements and chemical safety assessment – Chapter R.7b: Endpoint Specific Guidance. European Chemicals Agency
Conclusion on classification
Diurea 8 showed no acute toxicity to aquatic organisms at up to 100 mg/L WAF and therefore it does not meet the criteria for classification as acutely toxic to the aquatic environment under the DSD or the CLP regulations.
Chronic aquatic toxicity data for Diurea 8 are only available for algae. These data would not result in a chronic classification under the 2ndATP to the CLP. Diurea 8 only occurs in a grease base and its octanol-water partition coefficient is estimated to be very high, indicating that it would reside in the grease base and not partition out into the aquatic environment. The substance is therefore not expected to be available for bioaccumulation. As the substance does not show acute toxicity at up to 100 mg/L, the substances does not meet the criteria for classification for chronic toxicity to aquatic organisms.
According to ECHA’s Guidance on information requirements and chemical safety assessment Part B: Hazard Assessment (2011), if no adverse effects have been observed in studies at the highest recommended concentrations/doses tested, this would normally indicate that no hazard has been identified and no DNEL or PNEC can be derived. Hence exposure assessment for that route of exposure, type of effect or protection target would not be needed.
Reference
ECHA (2011) Guidance on information requirements and chemical safety assessment – Part B: Hazard Assessment. European Chemical Agency
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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