Registration Dossier
Registration Dossier
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EC number: 201-207-0 | CAS number: 79-43-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1941
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 951
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dichloroacetic acid
- EC Number:
- 201-207-0
- EC Name:
- Dichloroacetic acid
- Cas Number:
- 79-43-6
- Molecular formula:
- C2H2Cl2O2
- IUPAC Name:
- 2,2-dichloroacetic acid
- Test material form:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: None of our earlier papers have pointed out that, except in rare cases, all single oral doses are given in this laboratory to animals which have not been fasted overnight. In the few instances where we have made comparisons, the LD50 determined on fasted rats is lower than that on animals not fasted by only some 20 or 30%, a difference on the borderline of statistical significance and not great enough to influence evaluation of practical hazards.
Administration / exposure
- Route of administration:
- oral: unspecified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 820 mg/kg bw
Applicant's summary and conclusion
- Conclusions:
- The oral LD50 in rats was 2820 mg /kg bw.
- Executive summary:
The oral LD50 in rats was 2820 mg /kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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