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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1941
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication which meets basic scientific principles.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1951

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Dichloroacetic acid
EC Number:
201-207-0
EC Name:
Dichloroacetic acid
Cas Number:
79-43-6
Molecular formula:
C2H2Cl2O2
IUPAC Name:
2,2-dichloroacetic acid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Details on study design:
- Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
0.51 mL/kg bw

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Dermal LD50 of dichloroacetic acid in rabbits was 0.51 mL/kg bw.
Executive summary:

Dermal LD50 of dichloroacetic acid in rabbits was 0.51 mL/kg bw. Taking into account a density of 1.563 g/cm3 (mL), corresponding LD50 is 0.797 g/kg bw or 797 mg/kg bw.