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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Supporting data were available, indicating that dichloroacetic acid is irritating to corrosive on rabbit skin and eye. Further testing is waived and most conservative classification as skin corrosive and irriversible effects in eyes are proposed.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1951
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Publication supporting the waiving arguments.
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
no
Species:
rabbit
Strain:
not specified
Type of coverage:
not specified
Remarks on result:
other: Primary skin irritation on rabbits was 7/10.
Remarks:
no details reported
Irritant / corrosive response data:
slightly irritating
Interpretation of results:
slightly irritating
Remarks:
Migrated information
Conclusions:
The grade of primary irritation hazard given is explained by Smyth, Carpenter and Weil. Primary skin irritation on rabbits was 7/10.
Executive summary:

Primary skin irritation grade on rabbits was 7/10 in a skin irritation and corrosion study in rabbits.

Therefore most conservatie classification as skin corrosive is proposed and further testing is avoided.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation
Remarks:
no data
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1951
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Publication supporting the waiving arguments.
Reason / purpose for cross-reference:
reference to other study
Principles of method if other than guideline:
no data
GLP compliance:
no
Species:
rabbit
Strain:
not specified
Controls:
not specified
Amount / concentration applied:
no data
Duration of treatment / exposure:
no data
Observation period (in vivo):
no data
Number of animals or in vitro replicates:
no data
Details on study design:
no data
Remarks on result:
other: strongly irritating
Irritant / corrosive response data:
strongly irritating
Interpretation of results:
highly corrosive
Remarks:
Migrated information
Conclusions:
The grade of eye hazard given is explained by Carpenter and Smyth. Eye injury in rabbits from fluid was 10/10.
Executive summary:

Eye iinjury in rabbits from fluid was 10/10, indicating highly corrosive activity. Therefore most conservatie classification as irriversible effects on the eyes is proposed and further testing is avoided.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

A primary skin irritation grade on rabbits was 7/10 in a supporting skin irritation and corrosion study in rabbits (Smyth et al., 1951).Further testing is waived and most conservative classification as skin corrosive is proposed.

In the same supportive rabbit study , eye injury from fluid was 10/10, indicating highly corrosive activity (Smyth et al., 1951). Further testing is waived, and most conservatie classification as irriversible effects on the eyes is proposed.

Justification for selection of skin irritation / corrosion endpoint:

Supporting study for waiving arguments.

Justification for selection of eye irritation endpoint:

Supporting study for waiving arguments.

Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Justification for classification or non-classification

Dichloroacetic acid is classified as skin corrosive according to the Directive 67/548/EEC, Annex VI with symbol C (Corrosive) and risk phrase R35 -Causes severe burns. According to CLP regulation (No. 1272/2008 of 16 December 2008), dichloroacetic acid is classified as corrosive Category 1, with signal word 'Danger' and hazard statement: H314 - Causes severe skin burns and eye damage.

Dichloroacetic acid is classified as corrosive to eyes according to the Directive 67/548/EEC, Annex VI with symbol Xi and risk phrase R41- Risk of serious damage to eyes. According to CLP regulation (No. 1272/2/2008 of 16 December 2008), dichloroacetic acid is classified as Category 1, with signal word 'Danger' and hazard statement: H318 -Causes serious eye damage.