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EC number: 618-690-2 | CAS number: 90982-32-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA 540/9-82-021
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- HPLC estimation method
- Media:
- soil
Test material
- Reference substance name:
- ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate
- EC Number:
- 618-690-2
- Cas Number:
- 90982-32-4
- Molecular formula:
- C15H15ClN4O6S
- IUPAC Name:
- ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate
- Test material form:
- solid
- Remarks:
- White
- Details on test material:
- 95 to >99% purity
Constituent 1
- Radiolabelling:
- yes
Study design
- Test temperature:
- 25°C
HPLC method
- Details on study design: HPLC method:
- The mobility of the test substance was studied on each soil type by soil thin-layer chromatography. Each soil sample was hammer-milled to a 1-5 μm particle size and coated as a 400 μm layer onto 20 cm x 20 cm glass plates. One microliter aliquots of the sample and reference standard solutions (1 mg compound/mL acetone) were spotted three cm from the bottom of each plate. The lower 0.5 cm of each plate was submerged in water and the water was allowed to ascend to a height of 10 cm. The plates were air dried for 24 hours and exposed to X-ray film (Kodak SB-5) for two weeks.
Batch equilibrium or other method
- Analytical monitoring:
- no
Matrix propertiesopen allclose all
- Matrix no.:
- #1
- Matrix type:
- sandy loam
- % Clay:
- 18
- % Silt:
- 21
- % Sand:
- 61
- % Org. carbon:
- 2.1
- pH:
- 6.5
- CEC:
- 6.6 meq/100 g soil d.w.
- Matrix no.:
- #2
- Matrix type:
- silt loam
- % Clay:
- 17
- % Silt:
- 81
- % Sand:
- 2
- % Org. carbon:
- 4.3
- pH:
- 5.4
- CEC:
- 21.1 meq/100 g soil d.w.
- Matrix no.:
- #3
- Matrix type:
- silt loam
- % Clay:
- 5
- % Silt:
- 83
- % Sand:
- 12
- % Org. carbon:
- 7.5
- pH:
- 5.2
- CEC:
- 15.5 meq/100 g soil d.w.
- Matrix no.:
- #4
- Matrix type:
- sandy loam
- % Clay:
- 7
- % Silt:
- 33
- % Sand:
- 60
- % Org. carbon:
- 1.1
- pH:
- 6.6
- CEC:
- 5.3 meq/100 g soil d.w.
Results and discussion
Adsorption coefficientopen allclose all
- Key result
- Sample No.:
- #1
- Type:
- other: Ka
- Value:
- 0.43 other: µg/g
- pH:
- 6.5
- Temp.:
- 25 °C
- Matrix:
- Cecil sandy loam
- % Org. carbon:
- 2.1
- Key result
- Sample No.:
- #2
- Type:
- other: Ka
- Value:
- 3.2 other: µg/g
- pH:
- 5.4
- Temp.:
- 25 °C
- Matrix:
- Flanagan silt loam
- % Org. carbon:
- 4.3
- Key result
- Sample No.:
- #3
- Type:
- other: Ka
- Value:
- 7.4 other: µg/g
- pH:
- 5.2
- Temp.:
- 25 °C
- Matrix:
- Keyport silt loam
- % Org. carbon:
- 7.5
- Key result
- Sample No.:
- #4
- Type:
- other: Ka
- Value:
- 0.19 other: µg/g
- pH:
- 6.6
- Temp.:
- 25 °C
- Matrix:
- Woodstown sandy loam
- % Org. carbon:
- 1.1
- Key result
- Sample No.:
- #1
- Type:
- Kd
- Value:
- 0.96 other: µg/g
- pH:
- 6.5
- Temp.:
- 25 °C
- Matrix:
- Cecil sandy loam
- % Org. carbon:
- 2.1
- Key result
- Sample No.:
- #2
- Type:
- Kd
- Value:
- 3.7 other: µg/g
- pH:
- 5.4
- Temp.:
- 25 °C
- Matrix:
- Flanagan silt loam
- % Org. carbon:
- 4.3
- Key result
- Sample No.:
- #4
- Type:
- Kd
- Value:
- 0.24 other: µg/g
- pH:
- 6.6
- Temp.:
- 25 °C
- Matrix:
- Woodstown sandy loam
- % Org. carbon:
- 1.1
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance was very weakly adsorbed (Ka = 0.2-0.4) on the two sandy loam soils (Cecil sandy loam and Woodstown sandy loam) and only weakly adsorbed (Ka = 3-7) on the two silt loam soils (Flanagan silt loam and Keyport silt loam).
- Executive summary:
Adsorption, desorption, and soil thin-layer chromatography studies were conducted on Cecil sandy loam, Flanagan silt loam, Keyport silt loam, and Woodstown sandy loam soils. The mobility of the test substance varied from low mobility (EPA Class 2) to mobile (EPA Class 4) based on the results of the soil thin-layer chromatography study. The Rf values were similar to those of terbacil but appeared to be more highly dependent on the percent organic matter content of the soil.
The test substance was very weakly adsorbed (Ka = 0.2-0.4) on the two sandy loam soils (Cecil sandy loam and Woodstown sandy loam) and only weakly adsorbed (Ka = 3-7) on the two silt loam soils (Flanagan silt loam and Keyport silt loam).
Adsorbed radioactivity was readily desorbed for the sandy loam soils (Cecil sandy loam and Woodstown sandy loam) but more tightly retained on the silt loams. This ease of desorption appears to be inversely proportional to the percent organic matter content of the soils (Flanagan silt loam and Keyport silt loam).
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