Reaction mass of phenol and tetraphenylphosphonium phenolate

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

sieving

Type of particle tested:

primary particle

Type of distribution:

mass based distribution

Mass median aerodynamic diameter:

60.51 µm

No.:

#1

Size:

>= 10 - <= 100 µm

Distribution:

100 %

Remarks on result:

other: sieve fraction nominal < 100 µm

Result: Sieve Fraction (< 100 µm):

weighted sample: 1.0132 g

weight fraction < 100 µm: 0.1356 g

mass fraction < 100 µm: 13.38 %

Statistical Data Sieve Fraction:

Counts	1287
	Mean diameter [µm]	Aspect Ratio
Minimum	11.30	1.04
Maximum	99.75	5.43
Arithmetic mean	43.27	1.65
Median	40.09	1.56
Standard deviation	20.01	0.45

Statistical Data Mass Fraction:

Particle Size	Sperical Volume [%]	Cubical Volume [%]
< 4 µm (respirable)	0.00	0.00
4 -10 µm (thoracic)	0.00	0.00
10 -100 µm (inhalative)	100.00	100.00
> 100 µm	0.00	0.00
Median (diameter µm)	60.51	57.91

Conclusion:

Accounting based on total sample weight

	Particle Size [µm]	Spherical Volume [%]
Mass Fraction	> 100	86.62
Sieve Fraction	> 100	0.00
Total (> 100 µm)		86.62
Sieve Fraction	10 -100 (inhalative)	13.38
Sieve Fraction	4 -10 (thoracic)	0.00
Sieve Fraction	< 4 (respirable)	0.00

Conclusions:

The MMAD (Mass Median Aerodynamic Diameter < 100 μm) of the test item has a value of 60.51 μm as spherical particles.

Executive summary:

Determination of the particle size distribution of the test item was determined by scanning electron microscopy after the samples was fractionated by a 100 μm sieve following OECD Guidelines No: 110 method B. For the determination of the particle size and the aspect ratio, 6 pictures have been taken by SEM (scanning electron microscope) at a magnification of 50 times. The MMAD (Mass Median Aerodynamic Diameter < 100 μm) has a value of 60.51 μm as spherical particles.

Description of key information

The MMAD (Mass Median Aerodynamic Diameter < 100 μm) of the test item has a value of 60.51 μm as spherical particles.

Additional information

Determination of the particle size distribution of the test item was determined by scanning electron microscopy after the samples was fractionated by a 100 μm sieve following OECD Guidelines No: 110 method B. For the determination of the particle size and the aspect ratio, 6 pictures have been taken by SEM (scanning electron microscope) at a magnification of 50 times. The MMAD (Mass Median Aerodynamic Diameter < 100 μm) has a value of 60.51 μm as spherical particles.