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EC number: 947-162-7
CAS number: -
the test item is not irritating to the skin and severely damaging the
eyes of rabbits
In a skin irritation test performed according to OECD 404 none of the
three rabbits exposed for 4 hours under semi-occulsive conditions to the
test substance showed any skin reaction (score 0.0 for erythema and
edema). Thus, the test substance is not irritating to the skin of
In an eye irritation study performed according to OECD 405 on three
rabbits the severity of eye irritation increased with time after
exposure. Maximal scores of 4 for erythema, 2 for iritis, 1 for redness
(with whitish deposits in the conjunctival sac, probably pus), and 3 for
edema. At day 20 the cornea appeared destroyed and evaluation was not
possible any more. The effects showed no reversibility within the
observation period of 21 days. The test substance is thus severely
damaging the eyes of rabbits.
Based on a study on rabbits following OECD 404 no irritation is
warranted for skin irritation.
Based on a study on rabbits following OECD 405 the test substance should
be regarded as severely damaging the eye (Eye Damage 1, H319) according
to EC 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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