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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report date:
1989

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1'-[methylenebis(sulphonyl)]diethylene
EC Number:
221-909-0
EC Name:
1,1'-[methylenebis(sulphonyl)]diethylene
Cas Number:
3278-22-6
Molecular formula:
C5H8O4S2
IUPAC Name:
(ethenesulfonyl)methanesulfonylethene

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified
Controls:
no
Observation period (in vivo):
48 hours
Number of animals or in vitro replicates:
2

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: mortality
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
other: The animal died a few hours after application
Irritation parameter:
cornea opacity score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
not determinable
Remarks:
No scores for cornea and iris could be given due to severe chemosis
Irritation parameter:
conjunctivae score
Remarks:
redness
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
other: The animal died a few hours after application
Irritation parameter:
chemosis score
Basis:
animal #1
Time point:
other: 1 h
Score:
4
Irritation parameter:
chemosis score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
other: The animal died a few hours after application
Irritation parameter:
other: mortality
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: The animal was found dead on day 2 of the study
Irritation parameter:
cornea opacity score
Basis:
animal #2
Time point:
other: 1 h
Score:
0
Irritation parameter:
cornea opacity score
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: The animal was found dead on day 2 of the study
Irritation parameter:
conjunctivae score
Remarks:
redness
Basis:
animal #2
Time point:
other: 1 h
Score:
1
Irritation parameter:
chemosis score
Basis:
animal #2
Time point:
other: 1 h
Score:
4
Irritation parameter:
chemosis score
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: The animal was found dead on day 2 of the study
Irritation parameter:
iris score
Basis:
animal #2
Time point:
other: 1 h
Score:
2
Irritation parameter:
iris score
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: The animal was found dead on day 2 of the study
Irritant / corrosive response data:
No scores for cornea and iris could be given to animal 1 due to severe chemosis.
Other effects:
Lacrimation was observed for both animals.
Both animals died within 48 hours after application.

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria
Conclusions:
V190110 appeared to be very toxic if applied to the eyes, resulting in mortality of both test animals within 48 hours after application.