Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989
Report Date:
1989

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified
Controls:
no
Observation period (in vivo):
48 hours
Number of animals or in vitro replicates:
2

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: mortality
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
other: The animal died a few hours after application
Irritation parameter:
cornea opacity score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
not determinable
Remarks:
No scores for cornea and iris could be given due to severe chemosis
Irritation parameter:
conjunctivae score
Remarks:
redness
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
other: The animal died a few hours after application
Irritation parameter:
chemosis score
Basis:
animal #1
Time point:
other: 1 h
Score:
4
Irritation parameter:
chemosis score
Basis:
animal #1
Time point:
24/48/72 h
Remarks on result:
other: The animal died a few hours after application
Irritation parameter:
other: mortality
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: The animal was found dead on day 2 of the study
Irritation parameter:
cornea opacity score
Basis:
animal #2
Time point:
other: 1 h
Score:
0
Irritation parameter:
cornea opacity score
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: The animal was found dead on day 2 of the study
Irritation parameter:
conjunctivae score
Remarks:
redness
Basis:
animal #2
Time point:
other: 1 h
Score:
1
Irritation parameter:
chemosis score
Basis:
animal #2
Time point:
other: 1 h
Score:
4
Irritation parameter:
chemosis score
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: The animal was found dead on day 2 of the study
Irritation parameter:
iris score
Basis:
animal #2
Time point:
other: 1 h
Score:
2
Irritation parameter:
iris score
Basis:
animal #2
Time point:
24/48/72 h
Remarks on result:
other: The animal was found dead on day 2 of the study
Irritant / corrosive response data:
No scores for cornea and iris could be given to animal 1 due to severe chemosis.
Other effects:
Lacrimation was observed for both animals.
Both animals died within 48 hours after application.

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria
Conclusions:
V190110 appeared to be very toxic if applied to the eyes, resulting in mortality of both test animals within 48 hours after application.