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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1989

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 406 (Skin Sensitisation)
GLP compliance:
not specified
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
An appropriate guinea pig maximisation test is available therefore an additional LLNA test was deemed unnecessary due to animal welfare.

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1'-[methylenebis(sulphonyl)]diethylene
EC Number:
221-909-0
EC Name:
1,1'-[methylenebis(sulphonyl)]diethylene
Cas Number:
3278-22-6
Molecular formula:
C5H8O4S2
IUPAC Name:
(ethenesulfonyl)methanesulfonylethene

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Induction
Route:
intradermal and epicutaneous
Vehicle:
not specified
Challengeopen allclose all
No.:
#1
Route:
intradermal and epicutaneous
Vehicle:
not specified
Concentration / amount:
0
No.:
#2
Route:
intradermal and epicutaneous
Vehicle:
not specified
Concentration / amount:
0.1%
No.:
#3
Route:
intradermal and epicutaneous
Vehicle:
not specified
Concentration / amount:
0.2%
No.:
#4
Route:
intradermal and epicutaneous
Vehicle:
not specified
Concentration / amount:
0.5%
No. of animals per dose:
20
Challenge controls:
One control group for each challenge
Positive control substance(s):
no

Results and discussion

In vivo (non-LLNA)

Resultsopen allclose all
Reading:
1st reading
Group:
negative control
Dose level:
0%
No. with + reactions:
0
Total no. in group:
20
Remarks on result:
no indication of skin sensitisation
Reading:
1st reading
Group:
test chemical
Dose level:
0.1%
No. with + reactions:
2
Total no. in group:
20
Reading:
1st reading
Group:
test chemical
Dose level:
0.2%
No. with + reactions:
4
Total no. in group:
20
Reading:
1st reading
Group:
test chemical
Dose level:
0.5%
No. with + reactions:
14
Total no. in group:
20
Group:
positive control
Remarks on result:
not measured/tested

Applicant's summary and conclusion

Interpretation of results:
Category 1A (indication of significant skin sensitising potential) based on GHS criteria
Conclusions:
Under the conditions used in this study, V190110 resulted in a sensitisation rate of 75 per cent after intracutaneous and epicutaneous application to the guinea pig.