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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1992
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
publication
Title:
BUA-Stoffbericht 81 - Ameisensäure, Formiate
Author:
n.a.
Year:
1992
Bibliographic source:
Beratergremium für Altstoffe (BUA) der Gesellschaft Deutscher Chemiker, S.Hirzel Wissenschaftliche Verlagsgesellschaft

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Open irritation test according to RTECS update 9001.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Formic acid
EC Number:
200-579-1
EC Name:
Formic acid
Cas Number:
64-18-6
Molecular formula:
CH2O2
IUPAC Name:
formic acid
Constituent 2
Chemical structure
Reference substance name:
Water
EC Number:
231-791-2
EC Name:
Water
Cas Number:
7732-18-5
Molecular formula:
H2O
IUPAC Name:
Water
Test material form:
liquid

Test animals

Species:
rabbit

Test system

Type of coverage:
open
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
610 mg
Duration of treatment / exposure:
not specified
Observation period:
not specified
Number of animals:
not specified

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
ca. 1
Reversibility:
not specified
Remarks on result:
probability of mild irritation
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
ca. 1
Reversibility:
not specified
Remarks on result:
probability of mild irritation
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
ca. 2
Reversibility:
not specified
Remarks on result:
probability of mild irritation
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
ca. 1
Reversibility:
not specified
Remarks on result:
probability of mild irritation
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
ca. 1
Reversibility:
not specified
Remarks on result:
probability of mild irritation
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
ca. 2
Reversibility:
not specified
Remarks on result:
probability of mild irritation

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
According to RTECS formic acid causes mild skin irritation.
Executive summary:

According to RTECS formic acid causes mild skin irritation.